Evidence map›Paper›PMID 41131688›Full record

ReviewExercise and sport sciences reviews2026

The Endothelium as a Central Mediator of Exercise-Induced Metabolism and Communication.

Siobhan M Craige

Abstract readReview
In one paragraph

Review in Exercise and sport sciences reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Siobhan M CraigeDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA.

Funding

Endothelial Reactive Oxygen Species in Exercise MetabolismR01AR083948 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SIOBHAN M CRAIGE · 2025 to 2026
$1.3M
Endothelial Reactive Oxygen Species in Exercise MetabolismR56AR083948 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CRAIGE, SIOBHAN M · 2024 to 2024
$354k
Endothelial Signaling in Exercise MetabolismR03AR083493 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CRAIGE, SIOBHAN M · 2024 to 2025
$138k
NIAMS NIH HHS R01 AR083948NIAMS NIH HHS R03 AR083493NIAMS NIH HHS R56 AR083948
6 · The paper itself

Abstract

Cells lining the capillary endothelium, endothelial cells (ECs), play central roles in local and systemic metabolisms by sensing and responding to exercise-induced stresses. ECs release and respond to many factors, coordinating intra- and interorgan communication, supporting angiogenesis, and enhancing oxidative and global metabolism. Their widespread distribution positions them as key regulators of exercise-induced metabolic rewiring.

Indexed as

Cell CommunicationEndothelial CellsEndothelium, VascularExerciseAnimalsHumansNeovascularization, Physiologicangiogenesiscellular crosstalkendotheliumexercise metabolismnitric oxide (NO)reactive oxygen species (ROS)

Identifiers

PMID41131688
PMCPMC12673906

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.