ReviewEndocrinology2025
Endocrine Examples of Phase Separation in Biology.
Review in Endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Beyond the canonical view: steroid receptor network plasticity and mechanosensitive chromatin integration in breast cancer.NAR cancer · 2026Review
- ChIP happens: from biochemical origins to the modern omics toolbox for understanding steroid hormone receptors.The Biochemical journal · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Over the past 15 years, groundbreaking discoveries have reshaped our understanding of how biomolecules are organized in space and time within cells, revealing that many cellular compartments are separated from their surroundings not by membranes but by physical forces arising from unique interactions among their biomolecular components. These interactions drive the compartmentalization of biomolecules through liquid-liquid phase separation (LLPS) into dynamic droplets, which can further stabilize through liquid-gel phase separation (LGPS). Phase separation plays essential roles across diverse biological systems, including the endocrine system, where it impacts the function on steroid hormone receptors (SHRs). SHRs are a family of nuclear receptors that transduce steroid signals to regulate transcription of thousands of genes, thereby supporting endocrine homeostasis and contributing to diseases when dysregulated. During gene activation, SHRs form high-density clusters at promoters and enhancers. This mini-review summarizes recent literature indicating that these clusters function as transcriptional condensates, where phase separation of SHRs and coregulators mediates chromatin remodeling and enhanced transcription. We also discuss hypotheses suggesting that SHR-driven LLPS at gene loci contributes to hormone therapy resistance, while a transition to LGPS causes reduced hormone responsiveness. Finally, advancements in SHR condensate-modifying drugs to create new therapeutic options for hormone therapy-resistant cancers are highlighted. Overall, emerging evidence on the phase properties of SHR condensates is transforming our understanding of the endocrine regulation and unleashing novel intervention strategies beyond targeting individual proteins.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.