Evidence map›Paper›PMID 41131763›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2025

[Role and mechanism of ubiquitin-specific protease 35 in ferroptosis of rheumatoid arthritis-fibroblast like synoviocytes].

Lianghua Feng, Lirong Hong, Yujia Chen, Xueming Cai

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lianghua FengDepartment of Rheumatology and Immunology, Xiamen Fifth Hospital, Xiamen 361101, Fujian, China.
Lirong HongDepartment of Rheumatology and Immunology, Xiamen Fifth Hospital, Xiamen 361101, Fujian, China.
Yujia ChenDepartment of Rheumatology and Immunology, Xiamen Fifth Hospital, Xiamen 361101, Fujian, China.
Xueming CaiDepartment of Rheumatology and Immunology, Xiamen Fifth Hospital, Xiamen 361101, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo elucidate the role and underlying mechanism of ubiquitin-specific protease 35 (USP35) in ferroptosis of rheumatoid arthritis-fibroblast like synoviocytes (RA-FLS), thereby enhancing our comprehension of the pathogenesis of RA and identifying potential therapeutic targets for its treatment.

methods(1) RA-FLS were cultured

results(1) Compared with the shNC +Erastin group, the cell viability of the shUSP35+Erastin group was significantly decreased (

conclusionUSP35 inhibits ferroptosis in RA-FLS, potentially through the increased expression of SLC7A11 and GPX4.

Indexed as

Arthritis, RheumatoidEndopeptidasesFerroptosisFibroblastsSynoviocytesUbiquitin-Specific ProteasesAmino Acid Transport System y+Cell LineCells, CulturedCell SurvivalHumansPiperazinesReactive Oxygen SpeciesAmino Acid Transport System y+EndopeptidaseserastinPiperazinesReactive Oxygen SpeciesSLC7A11 protein, humanUbiquitin-Specific ProteasesFerroptosisGlutathione peroxidase 4Rheumatoid arthritisSolute carrier family 7 member 11Ubiquitin-specific protease 35

Identifiers

PMID41131763
PMCPMC12549345

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.