Evidence map›Paper›PMID 41131966›Full record

SynthesisDiabetes, obesity & metabolism2026

Weight-reducing treatments are associated with an improvement in depression, functional health status, and quality of life: A meta-analysis of randomized controlled trials.

Giovanni Antonio Silverii, Matteo Monami, Francesco Rotella, Maurizio De Luca, Tommaso Viozzi, Rocco Barazzoni, Silvio Buscemi, Luca Busetto, Paolo Sbraccia, Edoardo Mannucci

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giovanni Antonio SilveriiAOU Careggi, Diabetology Unit - Experimental and Clinical Biomedical Sciences "Mario Serio" Department, University of Florence, Italy.ORCID 0000-0002-6695-3213
Matteo MonamiAOU Careggi, Diabetology Unit - Experimental and Clinical Biomedical Sciences "Mario Serio" Department, University of Florence, Italy.ORCID 0000-0001-9349-828X
Francesco RotellaAOU Careggi, Psychiatry Unit, Department of Health Sciences, University of Florence, Italy.
Maurizio De LucaDepartment of Medical, Surgical and Health Sciences, University of Trieste, Italy.
Tommaso ViozziAOU Careggi, Diabetology Unit - Experimental and Clinical Biomedical Sciences "Mario Serio" Department, University of Florence, Italy.
Rocco BarazzoniDepartment of Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Silvio BuscemiDepartment of Medicine, University of Padova, Padua, Italy.ORCID 0000-0003-0730-7649
Luca BusettoDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Paolo SbracciaDepartment of Systems Medicine, Internal Medicine Unit - Obesity Center, Teaching Hospital and University of Rome Tor Vergata, Rome, Italy.
Edoardo MannucciAOU Careggi, Diabetology Unit - Experimental and Clinical Biomedical Sciences "Mario Serio" Department, University of Florence, Italy.ORCID 0000-0001-9759-9408

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess whether there is a beneficial or detrimental effect of weight reduction on mental health. MATERIALS AND

methodsMeta-analysis of randomized trials performed for weight loss, in which weight loss at endpoint was greater than 5% in the intervention arm and smaller than 5% in the control arm, obtained with any surgical, endoscopic, or EMA-approved pharmacological intervention. The endpoints were the incidence of overall and specific psychiatric adverse events.

resultsWeight loss was associated with a reduced risk of major depression (MH-OR 0.45 95% CI [0.21, 0.94], I

conclusionWeight-reducing treatments were associated with a beneficial effect on quality of life and functional health status and a reduced risk of depression, without any safety signal for serious or non-serious psychiatric adverse events.

Indexed as

DepressionObesityQuality of LifeWeight LossFunctional StatusHealth StatusHumansRandomized Controlled Trials as Topicantiobesity drugbariatric surgeryeight managementmeta‐analysisobesity careobesity therapy

Identifiers

PMID41131966
PMCPMC12673451

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.