ArticleTranslational andrology and urology2025
Decellularized rat tubules for tissue engineering.
Article in Translational andrology and urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic kidney disease (CKD) remains a global health challenge, with tissue engineering strategies like decellularized scaffolds offering potential solutions for functional renal regeneration, yet hindered by the complexity of whole-organ recellularization. Since the recellularization process is limited in whole organs, we propose to decellularize renal tubules and assess whether they exhibit enhanced recellularization potential, thereby offering a novel strategy for kidney regeneration. Methods: This study presents a microscale approach utilizing decellularized rat renal tubules to address these limitations. Renal tubules were microdissected from rat kidneys and then subjected to decellularization treatment with 0.5% sodium dodecyl sulfate (SDS) for 2 minutes. The decellularized renal tubules were structurally and compositionally characterized through immunofluorescence, transmission electron microscopy (TEM), DNA quantification, and collagen IV enzyme-linked immunosorbent assay (ELISA). Results: We successfully obtained decellularized renal tubule scaffolds, in which cellular components were removed while tubular basement membranes and extracellular matrix (ECM) architecture were preserved. TEM confirmed the ultrastructural integrity. Conclusions: The most significant contribution of this work is the establishment of a reproducible method for generating acellular renal tubule scaffolds that retain native ECM properties, providing a critical platform for studying cell-ECM interactions, disease modeling, and drug screening, thereby advancing targeted renal tissue engineering applications.
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