ReviewTranslational andrology and urology2025
A narrative review of the distribution and role of multipotent fibroblasts in penile tissue: implications for regenerative medicine and erectile dysfunction.
Review in Translational andrology and urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- From fibrosis to restoration: the multimodal 3 Ts protocol for Peyronie's disease.International journal of impotence research · 2026Review
- Using the International Index of Erectile Function-15 in Comparative Analysis Between Transcutaneous Electrical Nerve Stimulation of the Pudendal Nerve and Low-Level Laser Therapy in the Treatment of Erectile Dysfunction After COVID-19.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: Erectile dysfunction (ED) is a common male sexual disorder with multifactorial etiologies, including diabetes mellitus and cavernous nerve injury. Recent developments in single-cell RNA sequencing (scRNA-seq) have revealed substantial cellular heterogeneity within the corpus cavernosum, especially among fibroblast (FB) subclusters. This review aims to delineate the roles of these FB subclusters and their extracellular vesicles (EVs) in the pathogenesis and potential treatment of ED. Methods: A comprehensive literature review was conducted focusing on studies utilizing scRNA-seq to analyze human and murine corpus cavernosum tissues under physiological and ED-associated conditions. Key findings regarding FB subcluster classification, transcriptomic landscapes, and intercellular communication were synthesized, with particular attention to the fibrotic and regenerative roles of FB-derived EVs. Key Content and Findings: Distinct FB subclusters were identified, exhibiting profibrotic, regenerative, and signaling-related phenotypes. In ED models, including diabetes- and cavernous nerve injury-induced conditions, an increased prevalence of fibrotic FB phenotypes was observed, contributing to structural disruption and functional decline. FB-derived EVs were highlighted as pivotal mediators of paracrine signaling, influencing endothelial and smooth muscle cell function, modulating immune responses, and regulating extracellular matrix remodeling. Therapeutic administration of EVs demonstrated promising regenerative effects in preclinical ED models. Conclusions: FB subclusters and their EVs play central roles in the pathophysiology of ED, functioning in both deleterious and reparative capacities. Selective targeting of specific FB subpopulations or leveraging the therapeutic properties of FB-derived EVs may represent innovative strategies for managing ED, particularly in treatment-resistant cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.