Evidence map›Paper›PMID 41132674›Full record

ArticleFrontiers in immunology2025

Macrophage PTP1B regulates mitochondrial dynamics via the JAK2/STAT3-OPA1 axis and activates the cGAS/STING signaling pathway.

Xuefeng Lei, Diandian Qian, Wenzheng Zhang, Bin'an Zhao, Yabin Li, Hua Hao, Jing Yuan, Le Zhao, Centao Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. The Role of Phagocytic Cells in the Achilles Tendon.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuefeng Lei *Department of Orthopaedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Diandian Qian *Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China.
Wenzheng Zhang *Department of Orthopaedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Bin'an Zhao *Department of Sports Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yabin LiSchool of Life Sciences and Technology, Tongji University, Shanghai, China.
Hua HaoCollege of Traditional Chinese Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Jing YuanInnovation Center, Clinical Medicine Innovation Park, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Le ZhaoDepartment of Orthopedics, The Affiliated Changshu Hospital of Nantong University, Changshu No. 2 People's Hospital, Changshu, Jiangsu, China.
Centao LiuDepartment of Sports Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendinopathy is characterized by degenerative changes in tendon tissue, with its pathogenesis closely associated with macrophage-mediated chronic inflammation and mitochondrial dysfunction. Bioinformatics analysis of tendinopathic tissues revealed a significant upregulation of protein tyrosine phosphatase 1B (PTP1B) in macrophages, which accompanied with robust immune activation and marked Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) signaling pathway inhibition. In tendinopathy mouse models, both pro-inflammatory cytokines and PTP1B were found to be highly expressed in tendon tissues. However, conditional deletion of

Indexed as

Janus Kinase 2MacrophagesMembrane ProteinsMitochondrial DynamicsNucleotidyltransferasesProtein Tyrosine Phosphatase, Non-Receptor Type 1STAT3 Transcription FactorAnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDisease Models, AnimalGTP PhosphohydrolasesHumansMaleMiceMice, Inbred C57BLMice, KnockoutcGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseGTP PhosphohydrolasesJak2 protein, mouseJanus Kinase 2Membrane ProteinsNucleotidyltransferasesOpa1 protein, mouseProtein Tyrosine Phosphatase, Non-Receptor Type 1Ptpn1 protein, mouseStat3 protein, mouseSTAT3 Transcription FactorSting1 protein, mouseSTING ProteinJAK2/STAT3 signaling pathwaymacrophagesmitochondrial dynamicsPTP1Btendinopathy

Identifiers

PMID41132674
PMCPMC12540072

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.