Evidence map›Paper›PMID 41132678›Full record

ArticleFrontiers in immunology2025

Bexarotene signaling in human B and T lymphocytes induces gut-homing receptor expression.

Sina Kaiser, Ina Suhrkamp, Jinru He, Charlotte Helf, Christian D Sadik, Michael Weichenthal, Guido Heine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sina KaiserDepartment of Dermatology, Venereology, and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany.
Ina SuhrkampDepartment of Dermatology, Venereology, and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany.
Jinru HeZoological Institute, Kiel University, Kiel, Germany.
Charlotte HelfDepartment of Dermatology, Venereology, and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany.
Christian D SadikDepartment of Dermatology, Venereology, and Allergy, University of Lübeck, Lübeck, Germany.
Michael WeichenthalDepartment of Dermatology, Venereology, and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany.
Guido HeineDepartment of Dermatology, Venereology, and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Retinoic acid (RA) receptors (RARs) in human lymphocytes modulate the humoral and intestinal immune response by regulating target genes, including CD38, TGM2, and gut-homing markers. The impact of retinoid X receptors (RXRs) on this process is elusive. Objective: To determine the impact of the RXR ligand bexarotene (BXR) on the activation and differentiation of human B and T lymphocytes. Methods: Results: BXR induced the canonical retinoid target gene Conclusion: BXR via RXRs directly targets B and T lymphocytes, inducing retinoid target gene expression, including gut-homing receptors.

Indexed as

BexaroteneB-LymphocytesReceptors, Lymphocyte HomingT-LymphocytesADP-ribosyl Cyclase 1Antigens, Differentiation, T-LymphocyteCell DifferentiationFemaleHumansIntegrin beta ChainsLymphocyte ActivationMaleMembrane GlycoproteinsMiddle AgedReceptors, CCRRetinoid X ReceptorsADP-ribosyl Cyclase 1Antigens, Differentiation, T-LymphocyteBexaroteneCC chemokine receptor 9CTAGE1 protein, humanintegrin beta7Integrin beta ChainsMembrane GlycoproteinsReceptors, CCRReceptors, Lymphocyte HomingRetinoid X ReceptorsB cellsbexarotenehominglymphocytesretinoidrexinoidT cells

Identifiers

PMID41132678
PMCPMC12540313

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.