Evidence map›Paper›PMID 41132733›Full record

ArticleFrontiers in oncology2025

Case Report: Spontaneous pregnancy after fertility-preserving treatment in a patient with low-grade endometrial stromal sarcoma and literature review.

Manrong Wang, Pengfei Wu, Lulu Wang, Sijia Liu, Qujia Gama, Qiaoying Lv, Jinyu Zhang, Min Yu, Yiqin Wang, Fenghua Ma and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Manrong Wang *Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Pengfei Wu *Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Lulu WangDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Sijia LiuDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Qujia GamaDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Qiaoying LvDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Jinyu ZhangDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Min YuShanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China.
Yiqin WangShanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China.
Fenghua MaShanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China.
Weiwei ShanDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Xuezhen LuoDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Low-grade endometrial stromal sarcoma (LGESS) is a rare malignant tumor of the uterus, characterized by slow growth. Early-stage LGESS is associated with favorable survival, but it has a high recurrence rate. The primary treatment for this disease is full-staging surgery. In this report, we present a case to explore the potential for fertility-preserving treatment in young women with LGESS. Case presentation: A 29-year-old nulliparous patient diagnosed with stage IA LGESS underwent conservative treatment at the Obstetrics and Gynecology Hospital of Fudan University. After fertility-sparing surgery and three months of hormone treatment, no residual lesions were found. Subsequently, the patient conceived spontaneously and successfully delivered a healthy baby. However, she experienced recurrence eight months after delivery but declined hysterectomy and follow-up care. Conclusions: Currently, there is still no standard management protocol for fertility preservation therapy in LGESS. Both previously reported cases and our case suggest that fertility-sparing treatment may be an option for carefully selected patients with LGESS. Further research and larger clinical studies are necessary to explore fertility-preserving treatments for young nulliparous patients with LGESS to establish guidelines or consensus.

Indexed as

fertility-preserving treatmenthormone therapylow-grade endometrial stromal sarcoma (LGESS)recurrencespontaneous pregnancy

Identifiers

PMID41132733
PMCPMC12540163

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.