ArticleCureus2025
Clinical and Laboratory Correlates of Cerebral Blood Flow Velocities and Risks for Stroke Among Steady-State Sickle Cell Anemia Children: A Cross-Sectional Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Transcranial Doppler (TCD) ultrasound (US) is commonly used to assess cerebral blood flow velocity and identify abnormal flow patterns. Additionally, clinical and laboratory parameters could be useful for the early detection of sickle cell anemia (SCA) patients who are prone to developing stroke, especially in low-income settings. Objectives This study aims to correlate clinical and laboratory parameters with the risk of stroke according to TCD values in children with steady-state sickle cell anemia. Methods This study used a cross-sectional observational design, with study participants (steady-state SCA children, aged 2-14 years) recruited consecutively. The demographic details, general examination findings, frequency of crisis and blood transfusions, and duration of hydroxyurea usage, as well as the participants' weight, height, and nutritional indices, were recorded. The time-average mean of maximum velocity (TAMMV) was determined via transcranial Doppler imaging US of the middle and anterior cerebral arteries (MCAs and ACAs) on both sides of the head. The full blood count was determined via a hematology autoanalyzer, and an enzyme-linked immunosorbent assay (ELISA) kit was used to measure fetal hemoglobin. Statistical Package for Social Sciences software for Windows version 26 (IBM SPSS Inc., Chicago, IL) was used to determine the frequency, mean and standard deviation, associations, and correlations. The level of statistical significance was set at P < 0.05. Results A total of 110 SCA children were studied. The TAMMVs for normal height and stunted subjects were 133.79 ± 27.32 and 154.74 ± 37.18 cm/s, respectively (t = 2.138, p = 0.035), and the prevalence of abnormal velocity was significantly greater among stunted subjects (c
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