Synthesis and biological evaluation of pyrano and furano fused ring isoflavene derivatives.

Valerio Falasca, Eugene Yee, Shekh Sabir, Mohan Bhadbade, Daniel S Wenholz, David StC Black, Naresh Kumar

Abstract read

In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Design and Synthesis of Novel Isoflavene TANK-Binding Kinase 1 Inhibitors With Anti-Inflammatory Activity.ChemMedChem · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Valerio FalascaSchool of Chemistry, University of New South Wales Sydney NSW-2052 Australia n.kumar@unsw.edu.au.ORCID https://orcid.org/0000-0002-3592-9034

Eugene YeeSchool of Chemistry, University of New South Wales Sydney NSW-2052 Australia n.kumar@unsw.edu.au.

Shekh SabirSchool of Chemistry, University of New South Wales Sydney NSW-2052 Australia n.kumar@unsw.edu.au.ORCID https://orcid.org/0000-0002-3962-3040

Mohan BhadbadeSolid State and Elemental Analysis Unit, Mark Wainwright Analytical Centre, The University of New South Wales Sydney NSW 2052 Australia.

Daniel S WenholzSchool of Chemistry, University of New South Wales Sydney NSW-2052 Australia n.kumar@unsw.edu.au.

David StC BlackSchool of Chemistry, University of New South Wales Sydney NSW-2052 Australia n.kumar@unsw.edu.au.ORCID https://orcid.org/0000-0001-9300-4737

Naresh KumarSchool of Chemistry, University of New South Wales Sydney NSW-2052 Australia n.kumar@unsw.edu.au.ORCID https://orcid.org/0000-0002-0951-9621

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idronoxil (IDX) is a clinically tested isoflavene with anticancer and anti-inflammatory activity. While it has shown favourable safety and efficacy profiles in early trials, further optimisation is needed to improve its potency and pharmacokinetic properties. Structural modifications at the C6 and C7 positions of IDX have yielded promising leads; however, dual functionalisation of these sites remains underexplored. In this study, we report the synthesis of novel fused-ring IDX derivatives incorporating coumarin, pyran, and furan moieties

Identifiers

PMID41133121

DOI10.1039/d5ra06129f

PMCPMC12541709

What Socratic holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.