ArticleOncology letters2025
Prognostic value of the postoperative CALLY index in T1/T2 clear cell renal cell carcinoma.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Deciphering the potential of the C-reactive protein-albumin-lymphocyte index as a prognostic biomarker in malignancy: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Prognostic value of preoperative inflammatory cell-to-HDL cholesterol ratios in patients with non-metastatic clear cell renal cell carcinoma.Frontiers in oncology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying patients with renal cell carcinoma (RCC) at risk of postoperative recurrence remains challenging, particularly in those with early-stage disease. The objective of the present study was to evaluate the prognostic utility of the C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index and other haematological biomarkers in patients with pathologic T1/T2 clear-cell RCC (ccRCC). In total, data from 253 patients with pT1/T2 ccRCC who underwent nephrectomies were retrospectively analysed. Preoperative and postoperative levels of CRP, neutrophil-to-lymphocyte ratio (NLR) and CALLY index were assessed, and cut-off values were determined using receiver operating characteristic curves. Prognostic significance was evaluated using Kaplan-Meier and Cox regression analyses. A postoperative CALLY index of ≤2.163 was significantly associated with shorter progression-free survival [hazard ratio (HR)=3.64] and overall survival (HR=4.98). A preoperative NLR of ≥3.015 also predicted recurrence (HR=2.74). Furthermore, the postoperative CALLY index demonstrated the highest predictive accuracy for overall survival (area under the curve=0.8141). In conclusion, the postoperative CALLY index is a robust and accessible biomarker for recurrence and survival in patients with T1/T2 ccRCC, and may guide postoperative surveillance strategies.
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