ArticleAnnals of clinical and translational neurology2026
The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis.
Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimMultiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully revealed. Recent studies indicate that gray matter damage, as well as white matter lesions, are frequently seen in MS patients. Based on this background, the present study aimed to explore whether relapsing-remitting MS patients in the attack phase demonstrate different patterns of functional connectivity compared to those in a stable phase. MATERIAL AND
methodFor this purpose, resting-state fMRI findings of the attack (n = 5) and stable (n = 14) groups were examined.
resultsCompared to stable patients, the attack group appeared to show increased functional connectivity in several gray matter structures, including the left fusiform, posterior cingulate, orbitofrontal cortex, left supramarginal gyrus, thalamus, and precuneus.
conclusionThe findings indicate that patients in the inflammatory phase may exhibit increased activation in distinct gray matter regions relative to those not in the attack phase. This pattern might reflect the development of compensatory functional connections aimed at limiting potential clinical damage during relapse. Moreover, considering the diverse roles of these regions, their involvement could hypothetically be linked to immune-related processes, a possibility that warrants further investigation in larger cohorts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.