Evidence map›Paper›PMID 41133871›Full record

SynthesisJournal of clinical laboratory analysis2025

Antifungal Resistance of Candida spp. Isolates From HIV/AIDS Patients in Iran 1999-2024: A Systematic Review and Meta-Analysis.

Aliasghar Fakhri-Demeshghieh, Ali Yousefipour, Yousef Bolouki, Mohammad Sadegh Bigdeli, Erfan Zamani, Amirreza Farajkhoda, Alireza Salmani, Farzad Katiraee, Saied Bokaie

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aliasghar Fakhri-DemeshghiehDVM, Specialty Board-Certified in Epidemiology, Department of Food Hygiene and Quality Control, Epidemiology & Zoonoses Division of Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.ORCID https://orcid.org/0000-0003-1693-533X
Ali YousefipourDepartment of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Yousef BoloukiDepartment of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Mohammad Sadegh BigdeliDepartment of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Erfan ZamaniDepartment of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Amirreza FarajkhodaDepartment of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Alireza SalmaniDepartment of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.ORCID https://orcid.org/0009-0009-6477-683X
Farzad KatiraeeSection of Mycology, Department of Pathobiology, Faculty of Veterinary Medecine, University of Tabriz, Tabriz, Iran.ORCID https://orcid.org/0000-0002-8634-4378
Saied BokaieDepartment of Food Hygiene and Quality Control, Epidemiology & Zoonoses Division of Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntifungal resistance in Candida species in HIV/AIDS patients due to the scarcity of antifungal agents is important particularly in Iran with an estimate of 46,000 individuals living with HIV. This systematic review and meta-analysis aimed to determine the resistance rate of Candida spp. isolates from HIV/AIDS positive individuals in Iran from 1999 to 2024.

methodsPubMed, Scopus, Web of Science, MagIran, Scientific Information Database, and Google Scholar were searched and the title-and-abstract screening was performed independently by two review authors. The risk of bias assessment and the data extraction were performed independently by two review authors. Meta-analysis was performed using a random-effects model with Freeman-Tukey double arcsine transformation. This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020.

resultsFrom the retrieved 4925 references, 18 references belonging to 15 studies with 1318 Candida spp. isolates were included. The highest pooled resistance rate of Candida spp. was observed against clotrimazole (21%, 95% CI: 14-30, I

conclusionsThe use of amphotericin B, caspofungin, and nystatin for the treatment of Candida spp. in HIV-AIDS patients in Iran is recommended based on clinical indication.

trial registrationPROSPERO ID: CRD42024540580.

Indexed as

Acquired Immunodeficiency SyndromeAntifungal AgentsCandidaCandidiasisDrug Resistance, FungalHIV InfectionsHumansIranMicrobial Sensitivity TestsAntifungal AgentsCandidadrug resistanceHIVIransystematic review

Identifiers

PMID41133871
PMCPMC12618181

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.