ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Identifying Key Questions and Challenges in Microchimerism Biology.
Kristine J Chua, Rachel C Quilang, Katja Sallinger, Christina Athena Aktipis, Petra Arck, Diana W Bianchi, Hyun-Dong Chang, Henderson J Cleaves, Michael Eikmans, Heidi E S Fjeldstad and 22 more
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
32 authors.
Rachel C QuilangDepartment of Immunology, Leiden University Medical Center, Leiden, 2333 ZA, Netherlands.ORCID 0000-0002-2451-9718 Katja SallingerDepartment of Cell Biology, Histology & Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, 8010, Austria.ORCID 0000-0003-1130-2314 Christina Athena AktipisCenter for Evolution and Medicine, Arizona State University, Tempe, 85287, USA.ORCID 0000-0002-7128-670X Petra ArckDivision of Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.ORCID 0000-0002-2932-926X Diana W BianchiNational Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, USA.ORCID 0000-0001-9270-5267 Hyun-Dong ChangGerman Rheumatology Research Center, A Leibniz Institute (DRFZ), 10117, Berlin, Germany.
Henderson J CleavesDepartment of Chemistry, Howard University, Washington, D.C., 20059, USA.
Michael EikmansDepartment of Immunology, Leiden University Medical Center, Leiden, 2333 ZA, Netherlands.ORCID 0000-0002-9648-4227 Heidi E S FjeldstadDivision of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, 0424, Norway.ORCID 0000-0002-8538-3922 David HaigDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, 02138, USA.ORCID 0000-0001-7377-1605 Whitney E HarringtonDepartment of Pediatrics, University of Washington School of Medicine, Seattle, 98195, USA.ORCID 0000-0002-0121-978X Daniel P JacobsenDivision of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, 0424, Norway.ORCID 0000-0003-3229-6830 Mads Kamper-JørgensenDepartment of Public Health, University of Copenhagen, Copenhagen, DK-1165, Denmark.ORCID 0000-0001-6393-5258 Sami B KanaanTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, 98109, USA.ORCID 0000-0002-4608-0953 Kiarash KhosrotehraniFrazer institute, The University of Queensland, Woolloongabba, 4072, Australia.ORCID 0000-0002-6406-4076 J Lee NelsonMedicine, Rheumatology, University of Washington and Fred Hutchinson Cancer Center, Seattle, 98109, USA.ORCID 0000-0003-3163-1940 Tiffany D PanCenter for Studies in Demography and Ecology, University of Washington, Seattle, 98195, USA.ORCID 0000-0001-6646-8552 Jelmer R PrinsObstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, 9700 AB, The Netherlands.ORCID 0000-0002-3984-2163 Frank A SchildbergDepartment of Orthopedics and Trauma Surgery, University Hospital Bonn, 53127, Bonn, Germany.ORCID 0000-0003-0797-1945 Anne Cathrine StaffDivision of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, 0424, Norway.ORCID 0000-0001-9247-5721 Anders StåhlbergSahlgrenska Center for Cancer Research, Department of Laboratory Medicine, Wallenberg Centre for Molecular and Translational Medicine, Science for Life Laboratory, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 405 30, Sweden.ORCID 0000-0003-4243-0191 Ina A StelzerPathology, Center for Perinatal Discovery, University of California San Diego, La Jolla, 92037, USA.ORCID 0000-0002-9974-4661 Christopher UrbschatDivision of Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.ORCID 0000-0002-8866-9133 Sing Sing WayCenter for Inflammation and Tolerance, Cincinnati Children's Hospital, Cincinnati, 45229, USA.ORCID 0000-0001-8948-1952 Melissa A WilsonNational Human Genome Research Institute, National Institutes of Health Bethesda, Bethesda, 20892, USA.ORCID 0000-0002-2614-0285 Jody YeDivision of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, 10461, USA.ORCID 0000-0003-0926-6107 Thomas KroneisDepartment of Cell Biology, Histology & Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, 8010, Austria.ORCID 0000-0002-4761-9340 Amy M BoddyDepartment of Anthropology, University of California Santa Barbara, Santa Barbara, 93106, USA.ORCID 0000-0002-7990-2415 Funding
Intramural Research Program of the National Human Genome Research Institute, National Institutes of HealthJohn Templeton Foundation 62214
6 · The paper itselfAbstract
Microchimerism research has recently gained renewed attention despite known existence of these rare cells for decades. Fetal and maternal microchimeric-derived cells may have functional capabilities, and are increasingly associated with both beneficial and adverse health outcomes. Yet, establishing the role of microchimerism in health has been largely constrained methodologically and theoretically. The Microchimerism, Human Health, and Evolution Project address these challenges by calling on 29 leading microchimerism experts to put forth key research questions that can substantially advance the field. Seven major categories are identified: function and mechanism; microchimerism in interventions, treatment, and transplant; mapping "generational microchimerism"; evolution; microchimerism detection; appropriate experimental model systems; and definition of microchimerism. Identifying these questions - and continuing to find answers - will be crucial for advancing the knowledge of microchimerism in health and disease.
Indexed as
ChimerismAnimalsFemaleHumansMaleautoimmunitydetection methodsevolutionimmune tolerancematernal‐fetal interactionmicrochimerismpregnancy
Identifiers
PMID41134118
PMCPMC12752559
What Socratic holds
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LicenceCC BY
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