ArticleAging clinical and experimental research2025
Sex- and Age-Stratified relative handgrip strength and risk of eight chronic diseases in Middle-Aged and older adults: evidence from a National aging cohort study in China.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveIdentifying cost-effective biomarkers for chronic disease screening remains a global challenge. This study examined sex- and age-specific associations between relative handgrip strength (RHGS) and eight chronic diseases to inform targeted screening and resource allocation.
methodsLongitudinal data from 11,415 participants in the China Health and Retirement Longitudinal Study (CHARLS) aged ≥ 45 years were analyzed. Participants were stratified into sex-specific, body mass index-adjusted RHGS quartiles. Multivariable Cox proportional hazards models were used to examine associations between RHGS and risks of diabetes, dyslipidemia, low cognitive performance, depression, heart disease, hypertension, stroke, and arthritis, stratified by sex and age group.
resultsOver a median follow-up of 84 months, higher RHGS quartiles were linked to lower risks of diabetes, dyslipidemia, low cognitive performance, and stroke. In older males, the highest quartile was associated with a 53% lower risk of low cognitive performance and a nonlinear relationship with diabetes risk. In middle-aged males, the highest quartile meant a 64% lower risk of dyslipidemia. Among females, higher RHGS was associated with cardiovascular disease and reduced low cognitive risk in older females. Low baseline RHGS predicted higher risks, even if RHGS improved later.
conclusionsThis study supports incorporating RHGS assessment into routine midlife health screenings and adopting sex- and age-specific strategies to improve cost-effective disease prevention. Clinically, prioritize cognitive screening in older adults with low RHGS, focus on glucose and lipid disorders in middle-aged individuals with low RHGS, and emphasize cardiovascular risk assessment in middle-aged and older females with low RHGS.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.