Evidence mapPaperPMID 41134485Full record

ReviewProbiotics and antimicrobial proteins2026

The Potential Anticancer Mechanisms of Probiotics: A Comprehensive Review.

Chao Tang, Yue Qian, Shiyao Jia, Junyan Zhang, Yao Zhang, Yuting Ren, Huimin Yong, Jingguo Xu, Juan Kan, Jun Liu

Abstract readReview
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In one paragraph

Review in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chao TangCollege of Food Science and Engineering, Yangzhou University, Yangzhou, 225127, Jiangsu Province, China.
Yue QianCollege of Food Science and Engineering, Yangzhou University, Yangzhou, 225127, Jiangsu Province, China.
Shiyao JiaCollege of Food Science and Engineering, Yangzhou University, Yangzhou, 225127, Jiangsu Province, China.
Junyan ZhangCollege of Food Science and Engineering, Yangzhou University, Yangzhou, 225127, Jiangsu Province, China.
Yao ZhangCollege of Food Science and Engineering, Yangzhou University, Yangzhou, 225127, Jiangsu Province, China.
Yuting RenCollege of Food Science and Engineering, Yangzhou University, Yangzhou, 225127, Jiangsu Province, China.
Huimin YongCollege of Food Science and Engineering, Yangzhou University, Yangzhou, 225127, Jiangsu Province, China.
Jingguo XuCollege of Tourism and Cuisine Science, Yangzhou University, Yangzhou, 225127, Jiangsu Province, China. 008122@yzu.edu.cn.
Juan KanCollege of Food Science and Engineering, Yangzhou University, Yangzhou, 225127, Jiangsu Province, China.
Jun LiuCollege of Food Science and Engineering, Yangzhou University, Yangzhou, 225127, Jiangsu Province, China. junliu@yzu.edu.cn.

Funding

"Green Yangzhou Golden Phoenix" funding of Yangzhou 137013072High-level Talent Research Startup Fund of Yangzhou University 137012822 and 137012843National Outstanding Youth Science Fund Project of National Natural Science Foundation of China 32402268Natural Science Foundation of Jiangsu Province BK20230587
6 · The paper itself

Abstract

Cancer is a leading cause of mortality. With the changes in people's daily lifestyle and environmental pollution, the incidence of cancer has been increasing all over the world. Cancer not only increases patients' physical and mental burdens, but also brings a huge economic burden to the society. Thus, it is urgent to develop anti-cancer therapies with low side effects and high efficiency. Nowadays, probiotics have been considered as an effective strategy owing to their anti-tumor efficacy. In this review, we comprehensively summarize anti-cancer mechanisms of probiotics. Mechanistically, cell and animal experiments have revealed that probiotics prevent and/or alleviate cancer by blocking carcinogenesis-associated signaling pathways, initiating cancer cell apoptosis, detoxifying or reducing pro-carcinogenic compounds, regulating intestinal microbiota and their metabolites, increasing the efficacy of anti-cancer therapies, inhibiting inflammation, enhancing anti-tumor immunity, and reprogramming metabolism. Clinical evidence of probiotics in cancer treatment is also summarized. Finally, it discusses the future perspectives in the safety concerns, limitation use, and strain-specific effects of probiotics.

Indexed as

Antineoplastic AgentsNeoplasmsProbioticsAnimalsGastrointestinal MicrobiomeHumansAntineoplastic AgentsAnti-cancer immunityCancerGut microbiomeInflammationProbiotics

Identifiers

PMID41134485

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.