Evidence map›Paper›PMID 41134524›Full record

ArticleHepatology international2026

Comparison of diagnostic criteria for fatty liver disease in assessing cardiac dysfunction: a cross-sectional study.

Yun Kyung Cho, Myung Jin Kim, Eun Hee Kim, Min Jung Lee, Hyo-Jung Nam, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Hepatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yun Kyung ChoDepartment of Internal Medicine, Asan Medical Centre, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Myung Jin KimDepartment of Internal Medicine, Asan Medical Centre, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Eun Hee KimHealth Screening and Promotion Centre, Asan Medical Centre, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Min Jung LeeHealth Screening and Promotion Centre, Asan Medical Centre, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Hyo-Jung NamHealth Screening and Promotion Centre, Asan Medical Centre, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Woo Je LeeDepartment of Internal Medicine, Asan Medical Centre, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Hong-Kyu KimHealth Screening and Promotion Centre, Asan Medical Centre, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea. hkkim0801@amc.seoul.kr.ORCID http://orcid.org/0000-0002-7606-3521
Chang Hee JungDepartment of Internal Medicine, Asan Medical Centre, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea. chjung0204@gmail.com.ORCID http://orcid.org/0000-0003-4043-2396

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsMetabolic dysfunction-associated steatotic liver disease (MASLD) is an alternative to the established definition of metabolic dysfunction-associated fatty liver disease (MAFLD). We aimed to compare the utility of using MASLD and MAFLD in identifying individuals with impaired cardiac function.

methodsThis cross-sectional study included 7,094 participants who underwent routine health examinations at Asan Medical Centre in Seoul, Republic of Korea. Abdominal ultrasonography was performed to diagnose fatty liver disease. Transthoracic echocardiography was performed to assess cardiac function.

resultsMASLD and MAFLD were identified in 2,436 (34.3%) and 2,578 (36.3%) participants, respectively. Significantly lower E wave and E/A ratio with higher LA diameter, A wave, and E/E' ratio were observed in patients diagnosed with MASLD or MAFLD, indicating impaired diastolic function. The risk of left ventricular (LV) diastolic dysfunction is significantly higher in patients diagnosed with MAFLD only than in those diagnosed with MASLD only (24.2% vs 10.9%). Logistic regression analysis revealed, that compared with the presence of MASLD, the presence of MAFLD was independently associated with a 2.857-fold increase in the risk of LV diastolic dysfunction (95% confidence interval: 1.121-7.281, p = 0.028), even after adjusting for age, sex, and other clinical variables.

conclusionsThe MAFLD and MASLD criteria are associated with LV diastolic dysfunction; however, the MAFLD criteria more accurately reflect early cardiac impairment in a generally healthy population. Therefore, adopting the MAFLD criteria in clinical practice may facilitate improved cardiovascular risk stratification and early intervention.

Indexed as

Fatty LiverVentricular Dysfunction, LeftAdultAgedCross-Sectional StudiesEchocardiographyFemaleHumansMaleMiddle AgedRepublic of KoreaCardiac functionDiastolic dysfunctionMetabolic dysfunction-associated fatty liver disease

Identifiers

PMID41134524

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.