Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors.
Briana K ShimadaPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0003-1521-6966
Marissa WatanabePacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Nadia K Apo TakayamaPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0009-0009-1750-0320
Antonio G SoaresPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0001-5814-3475
Kayla A HallamPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0001-8211-3479
Orion S RiversPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Kris EwellPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Princess J D SantiagoPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0001-9111-2531
Sydonie M SwansonPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Pamela TohPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Naghum AlfulaijPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Marla J BerryPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0002-2428-586X
Lucia A SealePacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0002-0686-7516
Funding
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI JoAnn Umilani Tsark · 2017 to 2026
$59.5M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI JOHN Alan SHEPHERD · 1996 to 2026
$56.2M
The Control of Insect Metabolism through Nutrition-based SymbiosisP20GM125508 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Corrie Miller · 2018 to 2026
$21.2M
Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
Selenium Metabolism in the Heart: Impact of High Fructose and Low SeleniumP20GM139753 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Marla J Berry · 2022 to 2026
$13.3M
MECHANISM OF SELENOPROTEIN SYNTHESIS IN EUKARYOTESR01DK047320 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI BERRY, MARLA J · 1994 to 2020
$5.8M
Training in Cardiovascular Research at the University of HawaiiT32HL115505 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Michelle D Tallquist · 2012 to 2026
$3.8M
One Health Research Training Curriculum for Native Hawaiians and Pacific StudentsT34GM141986 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI GERSCHENSON, MARIANA, RIVERS, RACHEL · 2021 to 2025
$2.1M
Selenium metabolism in cold-induced adaptive thermogenesisR01DK128390 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI SEALE, LUCIA ANDREIA · 2021 to 2025
$2.0M
Investigating sex-specific metabolic effects of disrupted selenocysteine lyase and selenocysteine tRNA in Agrp hypothalamic neuronsF32DK124963 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI TORRES, DANIEL J. · 2020 to 2022
$206k
Hawai'i Community Foundation (HCF) #MedRes_2023_00002973HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL115505-11HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK128390HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK128390-03S1HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM139753HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM139753 - Sub project 5203HHS | NIH | National Institute of General Medical Sciences (NIGMS) T34GM141986NCI NIH HHS P30 CA071789NHLBI NIH HHS T32 HL115505NIDDK NIH HHS F32 DK124963NIDDK NIH HHS R01 DK047320NIDDK NIH HHS R01 DK128390NIGMS NIH HHS P20 GM125508NIGMS NIH HHS P20 GM139753NIGMS NIH HHS R24 GM137786NIGMS NIH HHS T34 GM141986NIMHD NIH HHS U54 MD007601
6 · The paper itself
Abstract
Dietary selenium (Se) deficiency elevates the risk of cardiometabolic disorders driven by excessive caloric dietary intake. A high-fat diet leads to redox imbalance and elevates lipid deposits in the heart regardless of sex. Selenium maintains redox homeostasis by regulating the levels of antioxidant selenoproteins, such as glutathione peroxidases 1 and 4 (GPX1,4) and thioredoxin reductases 1 and 2. Se-dependent tissues such as the heart have a recycling mechanism to maintain selenoprotein synthesis, especially when Se is limiting, carried out by the enzyme selenocysteine lyase (SCLY). Despite being highly reliant on Se to function properly, it remains unclear if SCLY is required to modulate Se and selenoprotein synthesis in the heart, particularly in obesity. In this study, we analyzed cardiomyocyte (CM) function and molecular modifications in the hearts of male and female whole body
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Cardiac redox imbalance upon disruption of selenocysteine decomposition in mice. · full record | Socratic