Evidence map›Paper›PMID 41134786›Full record

ArticlePloS one2025

Case-control study of autonomic symptoms in the setting of Long COVID with tilt table testing.

Matthew S Durstenfeld, Nirosh Mataraarachchi, Michael J Peluso, Marta Levkova-Clark, Veronica Schaffer, Emily A Fehrman, Grace Anderson, Diana Flores, Timothy J Henrich, Carlin S Long and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew S DurstenfeldDepartment of Medicine, University of California, San Francisco, California, United States of America.ORCID https://orcid.org/0000-0002-7612-3352
Nirosh MataraarachchiSchool of Medicine, University of California, San Francisco, United States of America.
Michael J PelusoDepartment of Medicine, University of California, San Francisco, California, United States of America.
Marta Levkova-ClarkDepartment of Medicine, University of California, San Francisco, California, United States of America.
Veronica SchafferDivision of Cardiology, University of California, Los Angeles, United States of America.
Emily A FehrmanDepartment of Medicine, University of California, San Francisco, California, United States of America.
Grace AndersonDepartment of Medicine, University of California, San Francisco, California, United States of America.
Diana FloresDepartment of Medicine, University of California, San Francisco, California, United States of America.
Timothy J HenrichDepartment of Medicine, University of California, San Francisco, California, United States of America.
Carlin S LongDepartment of Medicine, University of California, San Francisco, California, United States of America.
Steven G DeeksDepartment of Medicine, University of California, San Francisco, California, United States of America.
Priscilla Y HsueDivision of Cardiology, University of California, Los Angeles, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutonomic symptoms and orthostatic syndromes have been reported in Long COVID, but few studies have characterized findings using head up tilt table testing.

objectiveTo characterize autonomic responses to positional changes among individuals with Long COVID.

methodsWe assessed autonomic symptoms using the Composite Autonomic Symptom Scale 31 (COMPASS 31) instrument and performed head up tilt table testing for 30 minutes at 70 degrees among individuals with Long COVID and recovered comparators.

resultsWe included 26 participants (median age 56 years, 50% female median 25 months after first COVID): 16 with Long COVID and 10 recovered comparators. COMPASS 31 scores (0-100, higher is worse) were higher among those with Long COVID (median 30.5 vs 8, p = 0.003). Heart rate was 8 beats per minutes higher throughout tilt among those with Long COVID (95% CI 1.1 to 14.4; p = 0.02); there were no differences in blood pressure. Ten (63%) with Long COVID had symptoms during tilt compared to none among recovered participants (p = 0.003). Three (19%) with Long COVID had clinically abnormal findings: one each with orthostatic hypotension, and delayed orthostatic hypotension, and cardioinhibitory/vasovagal presyncope.

conclusionsAmong those with chronic autonomic symptoms in the setting of Long COVID, symptoms were common during tilt testing, and heart rate was increased, but most did not meet diagnostic criteria for a clinically abnormal hemodynamic response. Further research into mechanisms of autonomic symptoms in Long COVID is urgently needed.

Indexed as

Autonomic Nervous SystemAutonomic Nervous System DiseasesCOVID-19Tilt-Table TestAdultAgedBlood PressureCase-Control StudiesFemaleHeart RateHumansHypotension, OrthostaticMaleMiddle AgedPost-Acute COVID-19 SyndromeSARS-CoV-2

Identifiers

PMID41134786
PMCPMC12551903

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.