ReviewCurrent opinion in immunology2025
T follicular helper cell development during malaria.
Review in Current opinion in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Malaria is a life-threatening disease affecting more than 200 million people worldwide. CD4 T helper 1 (Th1) and T follicular helper (Tfh) cells are critical for stimulating phagocyte activation and humoral immunity, yet sterilizing, protective immune memory responses rarely develop. Malaria induces unique physiologic changes in the infected host that may give rise to nonconventional Tfh subsets and inefficient memory responses. While our understanding of the differentiation of conventional Tfh cells induced by Plasmodium infection is growing, how and whether malaria-associated environmental cues induce Tfh populations exhibiting mixed phenotype and function are not well defined. Moreover, little is known about the development and function of Tfh memory cells during malaria. In this review, we discuss the phenotype and known functions of Tfh subsets and memory development induced during malaria and highlight key priority knowledge gaps that remain to be addressed.
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