Evidence map›Paper›PMID 41135205›Full record

ArticleUltrasonics sonochemistry2025

Ultrasound-assisted enzyme extraction of Citri Exocarpium Rubrum (Juhong) polysaccharides and its structural characteristics and evaluation of improving Parkinson's disease through HDAC6/NLRP3 pathway.

Xianqun Meng, Sundong Lin, Mingtao Zhu, Siyi Wang, Haixue Kuang, Qiuhong Wang, Tian Xie

Abstract read
In one paragraph

Article in Ultrasonics sonochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xianqun MengCollege of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou 310000, China.
Sundong LinCollege of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou 310000, China.
Mingtao ZhuCollege of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou 310000, China.
Siyi WangHenan Key Laboratory of Natural Medicine Innovation and Transformation, Henan University, Zhengzhou 450000, China.
Haixue KuangKey Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China. Electronic address: khxandwqh@163.com.
Qiuhong WangKey Laboratory of Chinese medicinal herbs preparation, Guangdong Pharmaceutical University, Guangdong 510000, China. Electronic address: qhwang668@sina.com.
Tian XieCollege of Traditional Chinese Medicine, Wenzhou Medical University, Wenzhou 310000, China; Key Laboratory of Anticancer Traditional Chinese Medicine and Natural Drugs in the Province, Hangzhou Normal University, Hangzhou 325000, China. Electronic address: tianxie@hznu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Citri Exocarpium Rubrum (CER) has been utilized in food and medicine for over 2000 years both domestically and internationally. This study investigated the polysaccharide extraction process, structural characteristics, and biological activity of CER using ultrasonic-assisted enzyme extraction (UAE). The sugar yield of UCERP extracted via UAE, was 14.23 ± 0.12 %, with optimal extraction conditions of 70°C, 50 min of ultrasonic enzyme hydrolysis, 4.0 % cellulase, a solid-to-liquid ratio of 20: 1 mL/g, and ultrasonic power of 240 W. The monosaccharide composition of UCERP1-1, purified by isolation, includes rhamnose, arabinose, galactose, glucose, and galacturonic acid (ratio of 0.042: 0.202: 0.242: 0.06: 0.454). Moreover, the structural analysis revealed that UCERP1-1's fractions are primarily linked by a repeating unit: →[4)-α-D-GalAp-(1]

Indexed as

CellulaseChemical FractionationCitrusNLR Family, Pyrin Domain-Containing 3 ProteinParkinson DiseasePolysaccharidesSignal TransductionUltrasonic WavesAnimalsHumansMiceCellulaseNLR Family, Pyrin Domain-Containing 3 ProteinPolysaccharidesCitri Exocarpium Rubrum (Juhong) polysaccharidesHDAC6/NLRP3 pathwayParkinson’s diseaseUltrasound-assisted enzyme extraction

Identifiers

PMID41135205
PMCPMC12590259

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.