ArticleStem cell reports2025
Extracellular-vesicle-mediated transfer of let-7b/7c promotes the proliferation of transition-state spermatogonia in neonatal mouse testis.
Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- A rapid and robust translational model for testicular aging research.Histochemistry and cell biology · 2026Article
- The EV-mitochondrial outsourcing network as a therapeutic target for age-related testosterone deficiency: from network collapse to clinical intervention.Frontiers in endocrinology · 2026Review
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Authors and funding
8 authors.
Funding
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Abstract
The self-renewal and differentiation of spermatogonial stem cells (SSCs) play essential roles in spermatogenesis. Extracellular vesicle (EV) is a universal strategy for intercellular communications in stem cell niches. However, the involvement of EVs in regulating SSCs remains largely unknown. This study revealed that testis EVs from postnatal day 7 (PND7) neonatal mouse testis guided spermatogonia into a transit-amplifying state with increased proliferation while retaining their differentiation potential. We profiled the repertoires of proteins and small RNAs by proteomic and small RNA transcriptomic analyses, respectively. We further showed that the EVs secreted by undifferentiated spermatogonia and the Sertoli cell lines, but not from more differentiated germ cell lines, conveyed let-7b/7c microRNA (miRNA) cargoes to spermatogonia, which mediated the effect of EVs on spermatogonial transit amplification. Together, this study has deciphered crucial let-7b/7c cargoes of EV-mediated communication within the spermatogonial niche, providing a new insight into the regulation of SSCs and spermatogenesis.
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Registered trials
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