Evidence map›Paper›PMID 41136081›Full record

ReviewSleep medicine clinics2025

Opioids and Respiratory Related Consequences.

Jeremy E Orr, Deanna Hill, Robert L Owens

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sleep medicine clinics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jeremy E OrrDepartment of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: j1orr@health.ucsd.edu.
Deanna HillDepartment of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Robert L OwensDepartment of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Funding

The Impact of Sleep Disordered Breathing in People who use OpioidsK23HL151880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ORR, JEREMY ELLIOT · 2021 to 2025
$849k
NHLBI NIH HHS K23 HL151880
6 · The paper itself

Abstract

Opioids are widely used in acute and chronic pain management, but have significant respiratory effects that pose risks, especially in hospital settings. Opioid-induced respiratory depression occurs with opioids suppress the body's respiratory rate and response to CO2, leading to life-threatening gas exchange impairment. Chronic use of opioids causes central sleep apnea with an irregular breathing pattern, and contributes to complexity in managing obstructive sleep apnea. Mitigating respiratory risks of opioids involves limiting doses, careful monitoring, and sometimes the use of respiratory support like non-invasive ventilation.

Indexed as

Analgesics, OpioidRespiratory InsufficiencyHumansAnalgesics, OpioidCentral sleep apneaCO2 response suppressionNaloxoneObstructive sleep apneaOpioid-induced respiratory depressionOpioidsSleep-disordered breathing

Identifiers

PMID41136081
PMCPMC13477461

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.