SynthesisTranslational psychiatry2025
Shared cortical characteristics in major depressive disorder, anxiety disorder, and chronic pain: a structural MRI meta-analysis study.
Synthesis in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional brain alterations associated with acupuncture for chronic pain: a scoping review of fMRI studies.Frontiers in neuroscience · 2026Pooled it
- Structural brain alterations in chronic primary pain: a multimodal MRI study.NeuroImage. Clinical · 2026Article
- Alterations of static and dynamic functional connectivity of the nucleus accumbens subregions may be associated with chronic process of migraine: a resting-state fMRI study.The journal of headache and pain · 2026Article
- Impact of Postoperative Chronic Back Pain Syndrome on the Incidence of Psychiatric and Brain Disorders, and All-Cause Mortality.Journal of pain research · 2026Article
- Structural and Functional Brain Alterations in Postherpetic Neuralgia: A Systematic Review and Voxel-Wise Coordinate-Based Meta-Analysis via the SDM-PSI Method.Journal of pain research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain (CP) is closely related with major depressive disorder (MDD) and anxiety disorders (ANX), with high comorbidity and shared risk factors. Prior studies have demonstrated common neural correlates across the three disorders, but their neuroanatomic basis is not fully clear. Hence, the preregistered meta-analysis (CRD42019119709) intended to explore common alterations in cortical thickness among CP, MDD, and ANX, a widely used parameter for quantitatively assessing various cerebral conditions with high sensitivity to pathology in neuropsychology. A total of 68 studies comprising 3072 patients and 3427 healthy controls were finally included. Across the disorders, four common clusters with a significant reduction in cortical thickness were identified, including right insula, left anterior cingulate (AC), triangular part of the left inferior gyrus (IFG), and left middle temporal gyrus (MTG). Our findings suggested the shared cortical deficits involving ACC-insula/IFG circuit and left MTG in CP, MDD and ANX, revealing common neural correlates for cognitive and emotional processing in these highly comorbid disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.