ArticleScientific reports2025
Biochemical and structural improvements in ileum and colon with concurrent gut microbiota enhancement through intermittent fasting plasma infusions.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Probiotic co-administration attenuates developmental cafeteria diet-induced cellular stress and NLRP3 inflammasome signaling in the spleen.Frontiers in nutrition · 2026Article
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7 authors.
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Abstract
This study investigated the impact of intermittent fasting (IF) on older rats by administering plasma from 12-month-old male Sprague Dawley rats subjected to 35 days of IF, with 18-hour fasting intervals followed by 6-hour feeding periods. Over this period, 0.5 ml of plasma was transferred bi-daily to 24-month-old male rats, totaling 15 infusions. Infrared spectroscopy-based qualitative and quantitative analyses revealed significant changes in lipid, protein, and nucleic acid profiles, varying by tissue type and fasting regimen. Histological examination showed structural enhancements in the ileum and colon, along with reduced inflammatory markers TNF-α and COX-2, particularly with IF plasma. Additionally, plasma transfer markedly improved gut microbiota composition, increasing alpha diversity and adjusting the Firmicutes to Bacteroidetes ratio. High-Performance Liquid Chromatography results indicated elevated levels of key cecal short-chain fatty acids, suggesting enhanced gut health. These findings highlight the potential of plasma from intermittently fasting rats in modulating biomolecular profiles, intestinal tissue structure, gut microbiota, and SCFA production, offering integrated insights into intestinal health improvements.
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