Evidence map›Paper›PMID 41136552›Full record

ArticleScientific reports2025

Comparison of production methods for mesenchymal stem cell-derived small extracellular vesicles and evaluation of their effects on retinal pigment epithelium.

Nithikan Suthumchai, Payalak Sudcharee, Acharaporn Dambua, Patcharaporn Boonchu, Phatcharaphon Nopprang, Jakrin Bamrungthai, Juthakorn Poothong, Anucha Sacharoen, Siripakorn Sangkitporn, Adisak Trinavarat and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nithikan SuthumchaiCenter of Excellence for Microparticle and Exosome in Diseases, Department of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Payalak SudchareeCenter of Excellence for Microparticle and Exosome in Diseases, Department of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Acharaporn DambuaDepartment of Medical Science, Ministry of Public Health, Nonthaburi, Thailand.
Patcharaporn BoonchuDepartment of Medical Science, Ministry of Public Health, Nonthaburi, Thailand.
Phatcharaphon NopprangDepartment of Medical Science, Ministry of Public Health, Nonthaburi, Thailand.
Jakrin BamrungthaiDepartment of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Juthakorn PoothongDepartment of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Anucha SacharoenFaculty of Dentistry, Mahidol University, Bangkok, Thailand.
Siripakorn SangkitpornDepartment of Medical Science, Ministry of Public Health, Nonthaburi, Thailand.
Adisak TrinavaratDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
La-Ongsri AtchaneeyasakulDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. laongsri.ath@mahidol.ac.th.
Kovit PattanapanyasatCenter of Excellence for Microparticle and Exosome in Diseases, Department of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. kovit.pat@mahidol.ac.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The properties of extracellular vesicles depend on characteristics of the origin of cells. This study aimed to comprehensively evaluate a protocol for production of bone marrow mesenchymal stem cell-derived small extracellular vesicles (BM-MSC-sEVs) and investigate their effects on hydrogen peroxide (H

Indexed as

Extracellular VesiclesMesenchymal Stem CellsRetinal Pigment EpitheliumApoptosisCell LineCell ProliferationCells, CulturedCell SurvivalHumansHydrogen PeroxideHydrogen PeroxideApoptosisBone marrow-derived mesenchymal stem cellsProliferationSmall extracellular vesiclesTangential flow filtration

Identifiers

PMID41136552
PMCPMC12552664

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.