Evidence map›Paper›PMID 41136607›Full record

ArticleScientific reports2025

Positron emission tomography reveals increased myocardial glucose uptake in a subset of Friedreich ataxia patients.

R Mark Payne, Thomas M O'Connell, P Melanie Pride, Gregg R Wagner, George J Eckert, Tiffany R Johnson, Weinian Shou, Gary D Hutchins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

R Mark PayneDepartment of Pediatrics, Division of Cardiology, Indiana University School of Medicine, Indianapolis, IN, USA. rpayne@iu.edu.
Thomas M O'ConnellDepartment of Otolaryngology - Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
P Melanie PrideHerman B Wells Center for Pediatric Research, Department of Pediatrics (Cardiology), Indiana University School of Medicine, 1044 West Walnut, R4302, Indianapolis, IN, 46202, USA.
Gregg R WagnerSenior Scientific Manager, Stridebio, Durham, NC, USA.
George J EckertDepartment of Biostatistics, Indiana University, Indianapolis, IN, USA.
Tiffany R JohnsonDepartment of Pediatrics, Division of Cardiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Weinian ShouDepartment of Pediatrics, Division of Cardiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Gary D HutchinsDepartment of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA.

Funding

Transcriptional regulation of cardiac morphogenesisP01HL134599 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Lei Yang · 2017 to 2026
$25.7M
American Heart Association 11PRE7290079Indiana University Health Strategic Research InitiativeNHLBI NIH HHS P01 HL134599NIH HHS 5P01HL134599
6 · The paper itself

Abstract

Why some but not all patients with the rare disease Friedreich ataxia (FRDA) are at increased risk of poor cardiovascular outcome and death is unclear and unpredictable. We investigated the hypothesis that mitochondrial dysfunction in FRDA leads to altered patterns of myocardial metabolic substrate utilization. We recruited 5 healthy controls (Ctl) and 11 FRDA participants. All underwent fasting myocardial positron emission tomography (PET scan) with

Indexed as

Friedreich AtaxiaGlucoseMyocardiumPositron-Emission TomographyAdultAnimalsCase-Control StudiesFemaleFluorodeoxyglucose F18HumansMaleMiceMiddle AgedFluorodeoxyglucose F18Glucose

Identifiers

PMID41136607
PMCPMC12552483

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.