Evidence map›Paper›PMID 41136767›Full record

ArticleCurrent microbiology2025

HERV-K Envelope Induce a Humoral Response in Non-Hodgkin Lymphoma Patients.

Ilaria Cossu, Stefano Ruberto, Elisabetta Filippi, Elena R Simula, Marta Noli, Anna Mottula, Claudio Fozza, Leonardo A Sechi

Abstract read
In one paragraph

Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ilaria CossuDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy.
Stefano RubertoDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy.ORCID http://orcid.org/0000-0001-5478-999X
Elisabetta FilippiDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Elena R SimulaDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy.ORCID http://orcid.org/0000-0002-8946-2679
Marta NoliDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy.ORCID http://orcid.org/0000-0003-1087-4871
Anna MottulaDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Claudio FozzaDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.ORCID http://orcid.org/0000-0001-7253-5432
Leonardo A SechiDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy. sechila@uniss.it.ORCID http://orcid.org/0000-0003-0566-2049

Funding

Ministero della Salute PNRR-MCNT1-2023-12376993Regione Autonoma della Sardegna legge regionale 22 2022.
6 · The paper itself

Abstract

Haematological malignancies represent a heterogenous group of diseases, encompassing lymphomas, leukaemia, and multiple myeloma. Among these, the involvement of human endogenous retroviruses (HERVs) has been most consistently reported in lymphoma, while their role in leukaemia and multiple myeloma remains limited. This study investigated the humoral response to the envelope proteins of HERV-K and HERV-H in the peripheral blood of patients with multiple myeloma and non-Hodgkin lymphoma and assessed HERV-K envelope gene expression through an approach combining indirect ELISA and quantitative PCR. The study revealed an increased humoral response against the HERV-K envelope epitope in patients with non-Hodgkin lymphoma compared to matched healthy controls. However, no differences were observed in patients with multiple myeloma. Although limited to the humoral level, these findings support the relevance of HERV-K specific immune responses in non-Hodgkin lymphoma and provide a rationale for further investigation.

Indexed as

Antibodies, ViralEndogenous RetrovirusesImmunity, HumoralLymphoma, Non-HodgkinViral Envelope ProteinsAdultAgedFemaleHumansMaleMiddle AgedAntibodies, ViralViral Envelope Proteins

Identifiers

PMID41136767
PMCPMC12552366

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.