Evidence map›Paper›PMID 41136825›Full record

ArticleJournal of cancer survivorship : research and practice2025

Proof-of-concept for a randomized factorial design strategy to build a complex online support program for cancer survivors with psychiatric symptoms: the IN-FACT-0 feasibility trial.

Julia Winter, Nils Gasslander, Gustaf Rane, Felicia Sundström, Linda Björkhem-Bergman, Christel Hedman, Erland Axelsson

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06046573 (Pilot Study of Internet-Delivered Psychological Treatment for Cancer Survivors With Clinically Significant Psychiatric Symptoms), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06046573 nacompletednot on this map

Pilot Study of Internet-Delivered Psychological Treatment for Cancer Survivors With Clinically Significant Psychiatric Symptoms

TypeinterventionalSponsorKarolinska InstitutetRan2024 to 2024Enrolled40ConditionsCancer Survivors, Anxiety, DepressionArmsSupport and information, Behavioral activation, Systematic exposure with mindfulness training, Promotion of health behaviors
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julia WinterDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden. julia.winter@ki.se.
Nils GasslanderDivision of Clinical Psychology, Department of Psychology, Uppsala University, Uppsala, Sweden.
Gustaf RaneDivision of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Felicia SundströmDivision of Clinical Psychology, Department of Psychology, Uppsala University, Uppsala, Sweden.
Linda Björkhem-BergmanR & D Department, Stockholms Sjukhem Foundation, Stockholm, Sweden.
Christel HedmanDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden.
Erland AxelssonDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Funding

Fredrik och Ingrid Thurings Stiftelse 2022-00753Sjöbergstiftelsen 4-3584-2021
6 · The paper itself

Abstract

purposeInternet-delivered cognitive behavioral therapies and lifestyle interventions are promising for reducing psychiatric symptoms in cancer survivors, but little is known about the contribution of specific treatment components to observed effects. A randomized factorial trial could allow for evaluation of the unique contribution of treatment components to overall treatment effects. The IN-FACT-0 trial assessed the feasibility of such an approach for building an online support program for reducing long-term psychiatric symptoms in cancer survivors.

methodsIn a full factorial experiment, 40 survivors of breast, testicular, or thyroid cancer with clinically significant depressive symptoms, anxiety, or fear of recurrence were randomized to combinations of three treatment components: (i) behavioral activation, (ii) systematic exposure, and (iii) healthy lifestyle promotion. All groups, including a control group, received rudimentary support and kept a symptom diary.

resultsOn average, therapists rated the feasibility of the study design 9 on a scale from 0 ("not feasible at all") to 10 ("fully feasible"). The Credibility/Expectancy Scale mean was 36.6 (SD = 8.2). Participants initiated a mean of 6.1 (SD = 2.2, median = 7) out of 8 modules, and 90% (36/40) completed the post-treatment assessment. The mean Client Satisfaction Questionnaire score was 24.3 (SD = 5.7). One adverse event each was reported by 2/36 (6%) participants. No event was serious. The mean reduction was large in depressive symptoms (d = 0.83) and moderate in general anxiety (d = 0.55) and fear of recurrence (d = 0.54).

conclusionsThis randomized factorial trial design was feasible. IMPLICATIONS FOR CANCER SURVIVORS: This trial design may be used to develop effective, evidence-based interventions for cancer survivors with psychiatric symptoms.

trial registrationClinicalTrials.gov NCT06046573 (registered 2023-09-21).

Indexed as

Cancer survivorsFear of recurrenceFeasibility studiesProof of concept studyTelemedicine

Identifiers

PMID41136825

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.