Evidence map›Paper›PMID 41136950›Full record

Trial reportBMC infectious diseases2025

The combined effect of statin and vitamin C in patients with pulmonary septic shock: a single-center, double-blind clinical trial.

Behrooz Farzanegan, Navid Shafigh, Morteza Hasheminik, Haleh Alipour, Ali Behzadfar, Nava Safaee, Elnaz Shafigh, Mehdi Kazempour Dizaji

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Behrooz FarzaneganCritical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Navid Shafigh *Department of Anesthesiology and Critical Care Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. navid_shafigh2005@yahoo.com.
Morteza HasheminikDepartment of Nursing, Sab. C., Islamic Azad University, Sabzevar, Iran.
Haleh AlipourPediatric Intencive Care Departement, Mofid Pediatric Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ali Behzadfar *Critical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. alibehzadfarr@gmail.com.
Nava SafaeeCritical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Elnaz ShafighDepartment of Operative, Faculty of Dentistry, AJA University of Medical Sciences, Tehran, Iran.
Mehdi Kazempour DizajiMycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeTreating septic shock requires a multifactorial plan, such as anti-inflammatory drugs and newer drugs to reduce inflammation. This study investigated the effect of a combination (statin and vitamin C) on septic shock mortality and disease symptoms.

methodsIn this double-blind clinical trial study, 60 patients with septic shock hospitalized in the intensive care unit were assigned into two groups: intervention (1 gram of vitamin C was prescribed once a day for 5 days, and atorvastatin 40 mg daily) and control (routine treatment). Inflammatory parameters (C-reactive protein (CRP), lactate dehydrogenase (LDH), and serum ferritin (SF) and lactate), patient conditions, and Sequential Organ Failure Assessment (SOFA) scores were monitored and recorded on the fifth and seventh days of hospitalization, and the day of discharge from the intensive care unit (ICU).

resultsWhile mortality had no difference between the groups (p > 0.05), the duration of receiving inotrope was significantly shorter in the intervention group (p < 0.05). After the intervention, the measures of SOFA score, CRP, LDH, SF, and Lactate in the intervention group were significantly lower than those of the control group (p < 0.05). Besides, the measures of the biomarkers, including CRP, LDH, and SF, were significantly different in the intervention group (p < 0.05).

conclusionThe results of this study showed that the simultaneous use of statin and vitamin C can reduce inflammation indicators in ICU-admitted sepsis patients; however, this short-term intervention had no effect on mortality in the patients.

Indexed as

Ascorbic AcidAtorvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsShock, SepticAdultAgedC-Reactive ProteinDouble-Blind MethodDrug Therapy, CombinationFemaleHumansIntensive Care UnitsMaleMiddle AgedOrgan Dysfunction ScoresTreatment OutcomeAscorbic AcidAtorvastatinC-Reactive ProteinHydroxymethylglutaryl-CoA Reductase InhibitorsInflammationSeptic shockStatinVitamin C

Identifiers

PMID41136950
PMCPMC12553233

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.