Evidence mapPaperPMID 41137523Full record

ReviewGut microbes2025

G

Henok Ayalew Tegegne, Tor C Savidge

Abstract readReview
In one paragraph

Review in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Gut microbiota in health and disease.Molecular biomedicine · 2026
    Review
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  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Programming the tumor microenvironment through microbiome-driven mechanisms.Frontiers in cellular and infection microbiology · 2026
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Henok Ayalew TegegneDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Tor C SavidgeDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.

Funding

Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · 2024 to 2025
$7.2M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · BAYLOR COLLEGE OF MEDICINE · 2001 to 2025
$5.7M
PATHWAYS TO NEW BIOMARKERS IN RECURRENT ABDOMINAL PAIN IN CHILDRENR01NR013497 · NINR · BAYLOR COLLEGE OF MEDICINE · PI Tor C. Savidge · 2022 to 2024
$1.4M
Antimicrobial Resistance Training Program in the Texas Medical Center (AMR-TPT)T32AI179595 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · 2024 to 2025
$689k
NIAID NIH HHS P01 AI152999NIAID NIH HHS T32 AI141349NIAID NIH HHS T32 AI179595NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK130517NINR NIH HHS R01 NR013497
6 · The paper itself

Abstract

Gut microbiome metagenomics is emerging as a cornerstone of precision medicine, offering exceptional opportunities for improved diagnostics, risk stratification, and therapeutic development. Advances in high-throughput sequencing have uncovered robust microbial signatures linked to infectious, inflammatory, metabolic, and neoplastic diseases. Clinical applications now include pathogen detection, antimicrobial resistance profiling, microbiota-based therapies, and enterotype-guided patient stratification. However, translation into routine care is hindered by significant barriers including methodological variability, limited functional annotation, lack of bioinformatics standardization, and underrepresentation of global populations. This review synthesizes current translational strategies, emphasizing the need for hypothesis-driven designs, multi-omic integration, longitudinal and multi-center cohorts, and mechanistic validation. We also examine critical ethical, regulatory, and equity considerations shaping the clinical landscape. Realizing the full potential of microbiome-informed care will require globally harmonized standards, cross-sector collaboration, and inclusive frameworks that ensure scientific rigor and equitable benefit.

Indexed as

Gastrointestinal MicrobiomeMetagenomicsPrecision MedicineHumansantimicrobial resistancebiomarkersclinical translationGut microbiomemetagenomicsprecision medicine

Identifiers

PMID41137523
PMCPMC12562794

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.