ArticleAdvanced materials (Deerfield Beach, Fla.)2026
Mesenchymal Stem Cell-Inspired Microneedle Platform for NIR-responsive Immunomodulation and Accelerated Chronic Wound Healing.
Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Research advances in microneedle-exosome delivery systems for the treatment of multisystem diseases.Regenerative therapy · 2026Review
- Octopus-inspired suction-cup microneedle patch enables intralesional SMAD7/Budesonide co-delivery to disrupt TGF-β-driven fibrotic remodeling.Materials today. Bio · 2026Article
- In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Sustainable Polylactic Acid-Derived Polyurethane/MXene Microneedles for Stimulus-Responsive Transdermal Delivery.ACS polymers Au · 2026Article
- Microneedle-based platforms for wound healing: recent advances.Journal of materials chemistry. B · 2026Review
- AI-Guided 4D Printing of Carnivorous Plants-Inspired Microneedles for Accelerated Wound Healing.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Hyaluronic acid microneedle patch for transdermal delivery of naringin-loaded PEGylated terpesomes in a rat model of rheumatoid arthritis: Modulation TGF-β1, oxidative stress, and inflammation.International journal of pharmaceutics: X · 2026Article
- TeSe nanoparticle-integrated exosomes for accelerated diabetic Pressure ulcer healing via NIR-II triggered synergy.Biomaterials and biosystems · 2026Article
- Synergistic Regenerative Strategies: Combining Polydeoxyribonucleotide with Biochemical and Physical Agents.International journal of molecular sciences · 2026Review
- Engineered exosomes for diabetic foot ulcers: lessons learned, challenges remain.Military Medical Research · 2026Article
- Microneedle-Assisted Cell Delivery and Therapy.Research (Washington, D.C.) · 2026Review
- Applications of Nanomaterials in Chronic Wound Healing and Scar Prevention.International journal of nanomedicine · 2026Review
- Beyond immunomodulation: mechanisms and synergistic strategies of mesenchymal stem cells in promoting alveolar epithelial and endothelial repair in ARDS.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
Abstract
Chronic diabetic wounds present substantial clinical challenges owing to sustained inflammation, compromised vascularization, and inadequate retention of therapeutic medications. Accordingly, motivated by mesenchymal stem cells (MSCs) that actively secrete bioactive exosomes in response to stimuli from the tissue microenvironment, a biomimetic microneedle (MN) platform (MSCi@MN) is created to address these challenges. The MSCi@MN exhibits a dual-compartment structure composed of MSC-derived extracellular nanovesicles (NV) conjugated with polydeoxyribonucleotide (PDRN; DNA), referred to as NV-DNA, encapsulated within dissolvable MN tips, and photothermal-responsive MXene nanoparticles (MX) incorporated into the base layer for targeted near-infrared (NIR)-activated drug delivery. Upon NIR irradiation, MSCi@MN quickly releases NV-DNA, effectively modifying the immune responses by facilitating anti-inflammatory M2 macrophage polarization and activating tolerogenic dendritic cells, thereby establishing a regenerative microenvironment. Transcriptomic research has verified that NV-DNA synergistically promotes angiogenesis, cellular proliferation, and extracellular matrix remodeling by activating complementary molecular pathways. In animal models of diabetes, MSCi@MNs markedly expedite wound repair, diminish inflammation, enhance angiogenesis, and restore skin appendages without systemic adverse effects. This MSC-inspired approach, which integrates biologically sensitive controlled release with robust immunoregenerative capabilities, has substantial potential for clinical use in chronic wound treatment and regenerative medicine.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.