Evidence map›Paper›PMID 41137862›Full record

ArticleBiological trace element research2026

Zinc Ameliorates LPS-Induced Depressive-Like Behaviors Via Modulating Microglial Polarization.

ChenQi Li, Gen Miao, Wenjing Shi, Yangjuan Gu, Weiwei Li, Mengyu Cai, Yicui Qu, Yuxiao Tang, Hongtao Lu, Hongxia Li and 1 more

Abstract read
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In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

ChenQi Li *Department of Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Gen Miao *Department of Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Wenjing Shi *Department of Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Yangjuan GuDepartment of Nutrition, The Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, China.
Weiwei LiDepartment of Nutrition, The Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, China.
Mengyu CaiDepartment of Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Yicui QuDepartment of Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Yuxiao TangDepartment of Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China.
Hongtao LuDepartment of Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China. hongtao_lu1990@163.com.
Hongxia LiDepartment of Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China. hongxialove617@126.com.
Hui ShenDepartment of Nutrition and Food Hygiene, Naval Medical University, Shanghai, 200433, China. shenhui@smmu.edu.cn.

Funding

National Natural Science Foundation 81573150Natural Science Research Project of Shanghai Jiading District JDKW-2024-0013Project of Naval Medical University 2022MS002Project of Third Affiliated Hospital of Naval Medical University 2025QN09Shanghai Sailing Program 24YF2758300Shanghai Youth Program of Public Health Research 2024GKQ26
6 · The paper itself

Abstract

The neuroinflammation plays a crucial role in the pathogenesis and progression of depression. Microglia serve as the principal source of neuroinflammatory factors and regulate neuroinflammation via M1 and M2 polarization phenotypes. Moreover, NOD like receptor protein 3 (NLRP3) inflammasome pathway is considered to be important in regulating pro-inflammatory cytokine release in the hippocampus. Zinc supplementation has been shown to effectively alleviate depressive symptoms in patients. In this study, we utilized a lipopolysaccharide (LPS)-induced mouse model of depression and LPS-activated BV-2 cells to examine the impact of zinc supplementation. The findings indicated that zinc supplementation could: (1) ameliorate the depressive-like behaviors of the mouse model with inhibition of inflammatory cytokines and zinc homeostasis recovery. (2) induce the polarization of microglia towards the M2 phenotype in vivo and in vitro. (3) suppress the activation of the NLRP3 inflammasome pathway by impeding the expression of P2X purinergic receptor 7 (P2 × 7) induced by LPS, thereby regulating microglial polarization. This may represent a crucial pathway via which zinc inhibits the M1 polarization of microglia, promotes polarization towards the M2 phenotype, thus improving neuroinflammation and exerting an antidepressant effect.

Indexed as

Behavior, AnimalCell PolarityDepressionLipopolysaccharidesMicrogliaZincAnimalsDisease Models, AnimalInflammasomesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinInflammasomesLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseZincDepressionMicroglial polarizationNeuroinflammationNLRP3P2X7Zinc

Identifiers

PMID41137862

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.