ArticleMolecular genetics and genomics : MGG2025
Regulation of melanin synthesis in goat hair follicles by melatonin through the Wnt/β-catenin pathway.
Article in Molecular genetics and genomics : MGG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Human Secretomes, Plant Exosomes, and Hybrid Secretomes Intradermal Injections for Hair Regeneration: Experimental Study.Plastic and reconstructive surgery. Global open · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
To investigate the mechanism by which melatonin influences melanin production in goat melanocytes, and to provide a theoretical foundation for the genetic principles underlying animal hair color formation, dorsal skin tissues were collected approximately 5 cm behind the shoulder of 4-day-old Jiaohe black goats. Melanocytes were localized using immunohistochemistry and immunofluorescence techniques, isolated from hair follicle tissues through enzyme digestion, and treated with different concentrations of melatonin. Cell viability, proliferation, apoptosis, and melanin synthesis were assessed using CCK8, EdU, flow cytometry, and melanin content assays, respectively. Melanocytes were subjected to transcriptome sequencing, differential gene screening, and functional enrichment analyses. The expression of relevant genes and proteins was verified using real-time quantitative PCR and western blotting, respectively. Melanocytes were determined to be located above the hair follicle papilla and in the outer root sheath, and were successfully isolated and cultured. Melatonin inhibited melanocyte proliferation, promoted apoptosis, and inhibited melanin synthesis. After RNA sequencing, 952 and 1300 differentially expressed genes (DEGs) were screened by comparing the two groups respectively, which were mainly enriched in Melanogenesis and the Wnt signaling pathway. Validation experiments confirmed that melatonin inhibited the expression of genes and proteins related to the Wnt/β-catenin signaling pathway. Notably, treatment with an agonist of the Wnt/β-catenin pathway attenuated the inhibitory effect of melatonin. This study reveals that melatonin can reduce melanocyte viability, inhibit proliferation, promote apoptosis, reduce melanogenesis, and affect melanin synthesis through the Wnt/β-catenin signaling pathway. This study provides a theoretical basis for understanding the regulatory role of melatonin in hair color formation in animals.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.