ReviewCellular and molecular life sciences : CMLS2025
Leptin a potential link between obesity and depression.
Review in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glucagon-like peptide-1 receptor agonists and risk of depression: a systematic review and meta-analysis.BMC psychiatry · 2026Pooled it
- Levels of acylated and deacylated ghrelin are elevated in unmedicated patients with major depressive disorder and obesity: a cross-sectional study.Scientific reports · 2026Article
- Exploration of Early-Treatment-Associated Changes in Metabolic and Inflammatory Biomarkers in First-Episode Psychosis in Italian Patients.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity poses a serious threat to public health, acting as an epidemic that affects individuals of all ages, ethnicities, and sociocultural backgrounds. Besides, psychiatric disorders, especially depression, are also highly prevalent. Given the high impact of both types of conditions and their potential interrelation, they have become the focus of numerous research endeavors. In fact, the relationship between obesity and depression is often viewed as bidirectional. Leptin, a hormone released by adipose tissue that regulates energy balance and appetite, is closely linked to obesity. Recent research indicates that this hormone may also influence mood and behavior, which motivates the analysis of leptin's role in the shared pathophysiology between obesity and psychiatric disorders. The emerging relationship between obesity and neurodegeneration, attributed to the presence of chronic inflammation associated with this disease, prompts exploration of the potential role of leptin in this persistent inflammation, thus contributing to the neuroinflammatory state implicated in the genesis or evolution of depression. Therefore, in the present study, we aim to conduct a scoping review of the relationship between obesity and leptin with depression. According to the literature, there is an increase in leptin levels in depression, playing a pathophysiological role in the inflammation associated with the risk of depression in obesity. Nevertheless, further clinical studies are needed to fully understand the mechanisms and implications of leptin in the development of depression in obesity.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.