Evidence map›Paper›PMID 41139017›Full record

ArticleJournal of advanced research2026

Depletion of myeloid-derived Zbtb46

Shindy Soedono, Dan Hoang Nguyet Vo, Jiyeon Chang, Sharlene Sharlene, Princess Wendy Bayona, Sooyoung Kim, Jun Young Hong, Kae Won Cho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shindy SoedonoDepartment of Integrated Biomedical Science, Soonchunhyang University, Cheonan 31151, the Republic of Korea; Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, the Republic of Korea. Electronic address: shindysoedono@sch.ac.kr.
Dan Hoang Nguyet VoDepartment of Integrated Biomedical Science, Soonchunhyang University, Cheonan 31151, the Republic of Korea; Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, the Republic of Korea.
Jiyeon ChangDepartment of Integrated Biomedical Science, Soonchunhyang University, Cheonan 31151, the Republic of Korea; Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, the Republic of Korea.
Sharlene SharleneDepartment of Integrated Biomedical Science, Soonchunhyang University, Cheonan 31151, the Republic of Korea; Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, the Republic of Korea.
Princess Wendy BayonaDepartment of Integrated Biomedical Science, Soonchunhyang University, Cheonan 31151, the Republic of Korea; Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, the Republic of Korea.
Sooyoung KimDepartment of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, the Republic of Korea.
Jun Young HongDepartment of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, the Republic of Korea.
Kae Won ChoDepartment of Integrated Biomedical Science, Soonchunhyang University, Cheonan 31151, the Republic of Korea; Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, the Republic of Korea. Electronic address: kwcho@sch.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAdipose tissue (AT) immune cells regulate metabolic functions in obesity through both inflammatory and non-inflammatory pathways. However, the specific roles and mechanisms of individual AT immune cell types in glycemic control remain poorly understood.

objectiveThis study investigates the function of myeloid-derived Zbtb46

methodsChimeric Zbtb46-DTR mice were generated by transplanting bone marrow from Zbtb46-DTR donors into wild-type recipients with distinct congenic markers. Obesity was induced with a high-fat diet (HFD; 60% kcal from fat), and myeloid-derived Zbtb46

resultsInducible depletion of myeloid-derived Zbtb46

conclusionsThese findings uncover a novel, non-inflammatory role for ATDCs in glucose regulation via the DPP4/GLP-1/GLP-1R axis, positioning them as promising therapeutic targets for obesity and related metabolic diseases.

Indexed as

Dendritic CellsDipeptidyl Peptidase 4Glucagon-Like Peptide 1Glycemic ControlMyeloid CellsObesityAdipose TissueAnimalsDiet, High-FatMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionDipeptidyl Peptidase 4Dpp4 protein, mouseGlucagon-Like Peptide 1Adipose tissueDendritic cellDPP4GLP-1Glucose intoleranceInsulin resistanceObesity

Identifiers

PMID41139017
PMCPMC13316555

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.