ArticleJournal of nephrology2025
Sex-related disparities in cognitive impairment in kidney transplant patients with kidney failure.
Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Fatigue and Cognitive Impairment in Patients with Kidney Failure Not Requiring Kidney Replacement Therapy and Patients Receiving Hemodialysis: A Cross-Sectional Study.Brain sciences · 2026Article
- Transcriptomic Profiling in Aged Mice Reveals an Association Between Sevoflurane Anesthesia and Neurocognitive Dysfunction.Cellular and molecular neurobiology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are unexplained sex differences regarding prevalence, morbidity, and mortality in chronic kidney disease (CKD). Of note, females are less likely to be waitlisted and experience longer waiting times for kidney transplant (KTx). Recently, interest in cognitive impairment among CKD patients has increased due to its potential negative impact on therapeutic outcomes. This study aimed to investigate the influence of sex on cognitive impairment prevalence and patterns, as well as modifiable dementia risk factors, in KTx recipients.
methodsThis cross-sectional study screened KTx recipients for cognitive impairment using the Mini-Addenbrooke's Cognitive Examination. Demographic data, medical histories, and laboratory results were collected from medical records.
resultsThe study included 126 consecutive KTx recipients, predominantly male (62%). Males showed higher serum creatinine (1.57 vs. 1.25 mg/dL; p = 0.001), urea (59.50 vs. 55.00 mg/dL; p = 0.046), and uric acid (7.20 vs. 6.20 mg/dL; p = 0.012) levels compared to females. However, creatinine clearance rates did not differ significantly between sexes (49.03 ± 20.29 vs. 50.79 ± 21.7 mL/min/1.73 m
conclusionsThere was a high prevalence of cognitive impairment among KTx recipients, affecting both sexes equally. Male predominance in the study cohort likely reflects systemic disparities in transplant access. These findings highlight the importance of integrating sex-specific considerations into the management and follow-up care of KTx recipients.
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