ArticleFrontiers in medicine2025
A novel biomarker Ins60/ApoA for predicting diabetic kidney disease in newly diagnosed type 2 diabetes: a pilot study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: We performed this cross-sectional study to explore potential biomarkers for predicting diabetic kidney disease (DKD) in newly diagnosed type 2 diabetes mellitus (T2DM). Methods: A total of 623 patients were recruited from Xuzhou First People's Hospital and Nanjing First Hospital based on the electronic case records system. Patients were grouped according to their albuminuria-to-creatinine ratio (ACR) into two categories: ACR < 30 mg/g and ACR ≥ 30 mg/g. Biomarker levels between the two ACR groups were compared using an independent sample Results: The levels of total cholesterol, glycated hemoglobin (HbA1c), fasting C-peptide, fasting insulin, and prevalence of hypertension were higher, while the levels of red blood cell counts (RBC), hemoglobin, ApoA, and free triiodothyronine were lower in the ACR ≥ 30 mg/g group. Negative correlations were found between ACR ≥ 30 mg/g and RBC, hemoglobin, albumin, and NAFLD ( Conclusion: The ratio of Ins60/ApoA could be used as an alternative biomarker for predicting DKD in newly diagnosed T2DM patients.
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