ReviewOphthalmology science2026
Retinal and Choroidal Microvasculature at Different Myopia Severities: A Systematic Review and Meta-Analysis.
Review in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Reference Percentiles for Macular Vessel Density by OCT Angiography and Their Association with Systemic Diseases in Chinese Adults.Ophthalmology science · 2026Article
- Differential regulation of myopia progression by ON and OFF stimulation in guinea pigs.Eye and vision (London, England) · 2026Article
- Biphasic Change in Retinal Arterial Hemodynamics Amidst Systematic Perfusion Decline With Increasing Degree of Myopia.Investigative ophthalmology & visual science · 2026Article
- Normative Database and Determinants of Retinal and Choroidal Vessel Density in Tibetan Children.Children (Basel, Switzerland) · 2026Article
- Choroidal Structural and Vascular Changes During Myopia Progression and in Response to Myopia Control Interventions: A Systematic Review.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Developmental trajectories of visual acuity and associated determinants in Chinese primary school students: a longitudinal cohort study.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Topic: This study systematically evaluates changes in retinal and choroidal microvasculature with increasing myopia severity. Clinical Relevance: Conflicting results in reported studies on the changes in retinal and choroidal microvasculature with increasing myopia severity require comprehensive analysis to guide patient management. Methods: The PubMed, Embase, and Web of Science databases were thoroughly searched for studies published before May 8, 2025 on retinal or choroidal changes across different myopia severities. Included were studies with cross-sectional or prospective case-control and cohort designs that reported outcomes of foveal avascular zone (FAZ) area and vessel densities (VD) in the retina and choroid. The risk of bias was assessed by the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality tools. Funnel plot with Egger test assessed potential publication bias. Meta-regressions were conducted to identify potential moderators in subgroup meta-analyses with high heterogeneity. The protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO): CRD42023402550. Results: A total of 47 studies comprising 7293 eyes were included. Highly myopic eyes demonstrated significantly enlarged FAZ area in both the superficial capillary plexus (SCP) ( Conclusions: This meta-analysis revealed significantly enlarged FAZ areas and reduced VD in the macular and peripapillary regions with increasing myopia, especially in HM. These findings enhance the understanding of myopia-related fundus microvascular changes, guiding the clinical management and screening of patients with HM.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.