ArticleEJVES vascular forum2025
Overexpression of αVβ3 Integrin in an Aortic Aneurysm Murine Model: Confirmation in
Article in EJVES vascular forum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The pathophysiological mechanisms that occur in the wall of aortic aneurysms are not fully understood. Angiogenesis is a characteristic change in aneurysmal disease; αVβ3 integrin is a glycoprotein overexpressed in this biological process. This study aimed to evaluate angiogenic activity in a murine model of thoracic aortic aneurysm (TAA) using molecular imaging and immunofluorescence, and to assess differences in αVβ3 integrin expression in Methods: Eight Wistar rats underwent experimental induction of TAA with peri-adventitial calcium chloride (CaCl2) and were evaluated with micropositron emission tomography (MicroPET) using arginine-glycine-aspartate with gallium 68 ( Results: An overall MicroPET uptake was obtained in the murine models; the median standard uptake value of Conclusions: Significant differences in the angiogenic process were demonstrated with molecular imaging and immunofluorescence in the murine TAA model. Differences in αVβ3 integrin expression were confirmed when comparing diseased and non-diseased aortas in humans.
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