ArticleFrontiers in pharmacology2025
Forced intensity-controlled endurance training on a small-animal treadmill machine inducing murine cardiac hypertrophy: insights and comparison to voluntary running models.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Endurance training is associated with decreased cardiovascular-related morbidity and mortality. Cardiac hypertrophy is an adaptive mechanism, and murine exercise models for cardiac hypertrophy are still under discussion. Using a small-animal treadmill, a forced intensity-controlled training model was conducted to characterize cardiac hypertrophy in mice utilizing multimodal analyses and then compared to datasets of voluntary running mice. Wild-type male C57BL/6 mice at 8 weeks old were subjected to forced endurance training using a small-animal treadmill or sedentary age-matched control. Five different measurement points (0-, 2-, 4-, 8-, and 12 weeks) were used to assess phenotypic changes. Each training group was scanned using an ECG-gated
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