Evidence map›Paper›PMID 41142423›Full record

ArticleMaterials today. Bio2025

A protonation/degradation dual control pH-responsive LVF delivery system with rod-shaped core-shell structure for the treatment of bone infections.

Lei Chen, Jieyu Zhang, Xiashu Jiang, Bo Zhang, Yani Sun, Kang Zhao, Binghua Yao, Yufei Tang, Quanchang Tan, Zixiang Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lei ChenSchool of Science, Xi'an University of Technology, Xi'an, 710054, PR China.
Jieyu ZhangSchool of Science, Xi'an University of Technology, Xi'an, 710054, PR China.
Xiashu JiangSchool of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR China.
Bo ZhangSchool of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR China.
Yani SunSchool of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR China.
Kang ZhaoSchool of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR China.
Binghua YaoSchool of Science, Xi'an University of Technology, Xi'an, 710054, PR China.
Yufei TangSchool of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR China.
Quanchang TanInstitute of Orthopedics, Xi'jing Hospital, Fourth Military Medical University, Xi'an, 710032, PR China.
Zixiang WuInstitute of Orthopedics, Xi'jing Hospital, Fourth Military Medical University, Xi'an, 710032, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic-loaded poly(methyl methacrylate) (PMMA) bone cement was employed to inhibit bone infection and promote bone healing at the lesion site. However, there are several limitations, including a failure to release the antibiotic in response to the acidic environment of the bone infection, a mismatch between the drug release cycle and the healing cycle of human bone, inadequate mechanical strength, and inferior osteogenic properties. In this research, CaCO

Indexed as

Antibacterial activitiesOsteogenic propertiespH-responsive LVF releaseProtonationRod-shaped core-shell structure

Identifiers

PMID41142423
PMCPMC12553066

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.