Evidence map›Paper›PMID 41142782›Full record

ArticleFrontiers in immunology2025

Contribution of the bitter taste signaling pathway to lung inflammation during

Ling-Ling Liu, Feng Li, Meng-Min Zhu, Bo-Wen Niu, Yu Huang, Lixiang Chen, Hua Yang, Boyin Qin, Xiaohui Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ling-Ling Liu *Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan Univeristy, Shanghai, China.
Feng Li *Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan Univeristy, Shanghai, China.
Meng-Min ZhuDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan Univeristy, Shanghai, China.
Bo-Wen NiuDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan Univeristy, Shanghai, China.
Yu HuangDepartment of Biology, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Lixiang ChenDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan Univeristy, Shanghai, China.
Hua YangDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan Univeristy, Shanghai, China.
Boyin QinDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan Univeristy, Shanghai, China.
Xiaohui ZhouDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan Univeristy, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bitter taste receptors (TAS2Rs), initially identified for chemosensory roles in the tongue, are expressed in extraoral tissues, including the airways. However, to date, it remains unclear whether bitter signaling is associated with susceptibility to bacterial infection in the lower airways and whether bitter signaling actually participates in the immune response in lung infection has yet to be genetically established. Here, we investigated the role of TAS2R signaling in

Indexed as

PneumoniaPneumonia, StaphylococcalReceptors, G-Protein-CoupledSignal TransductionStaphylococcal InfectionsStaphylococcus aureusTasteAnimalsDisease Models, AnimalLungMiceMice, Inbred C57BLMice, KnockoutTaste Receptors, Type 2Receptors, G-Protein-CoupledTaste Receptors, Type 2bitter taste receptorcytokinesinflammationpneumoniaStaphylococcus aureus

Identifiers

PMID41142782
PMCPMC12545109

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.