ReviewFrontiers in immunology2025
The role of cGAS-STING signaling in HPV infection and HPV-related cancers.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Human Influenza Virus Infection: A Focus on Key Host Determinants Linked to Clinical Disease Severity.Viruses · 2026Review
- The Exploration of Therapeutic Antivirals for Human Papillomavirus in the Last 40 Years: Bibliometric Research.Pathogens (Basel, Switzerland) · 2026Article
- Precision management of cervical cancer emphasizes immunotherapy combination regimens and translational advances.Discover oncology · 2026Review
- Spatially organized macrophage-T-cell crosstalk in cervical cancer: insights from single-cell and spatial omics.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human papillomavirus (HPV) is a highly prevalent virus that primarily infects human epithelial cells, resulting in a significant health burden by causing conditions such as anogenital warts, cervical cancers, and head and neck squamous cell carcinoma. Although vaccination has been implemented for cancer prevention, a thorough understanding of anti-HPV immunity remains of critical importance for HPV-related disease management. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway forms a key signaling cascade within the innate immune system, which is activated by cytosolic DNA and functions through the production of type I interferon (IFN-I). Accumulating evidence indicates a correlation between the cGAS-STING pathway and HPV infection, as well as HPV-related malignancies, suggesting its potential as a promising therapeutic target. This review discusses the role of the cGAS-STING signaling pathway in HPV infection and HPV-related cancers, as well as potential therapeutic strategies that target this pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.