Evidence map›Paper›PMID 41142987›Full record

ArticleiScience2025

Adjuvants and MHCII modulate the immunogenicity of subdominant epitopes in

Daniel Ferrer Vinals, Mohammad Rafiul Hoque, Opeyemi Ernest Oludada, Ethan B Jansen, Catherine J Mitran, Jhon R Enterina, Matthew S Macauley, Michael T Hawkes, Stephanie K Yanow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel Ferrer VinalsSchool of Public Health, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Mohammad Rafiul HoqueSchool of Public Health, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Opeyemi Ernest OludadaSchool of Public Health, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Ethan B JansenSchool of Public Health, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Catherine J MitranSchool of Public Health, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Jhon R EnterinaDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Matthew S MacauleyDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Michael T HawkesDepartment of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada.
Stephanie K YanowSchool of Public Health, University of Alberta, Edmonton, AB T6G 2E1, Canada.

Funding

Exploiting cross-reactive, conserved epitopes in Plasmodium vivax to develop a vaccine against falciparum placental malaria.R01AI150944 · NIAID · UNIVERSITY OF ALBERTA · PI YANOW, STEPHANIE · 2020 to 2025
$1.9M
NIAID NIH HHS R01 AI150944
6 · The paper itself

Abstract

Antibody responses to protein antigens are driven by epitope hierarchies that promote the immunogenicity of select epitopes. For antigenically variable pathogens, immune responses toward conserved epitopes are critical to elicit strain-transcending antibodies, yet these epitopes are often subdominant. Designing vaccines that focus immune responses to these epitopes requires an understanding of which components can overcome subdominance. Using the

Indexed as

ImmunologyParasitologyVaccinology

Identifiers

PMID41142987
PMCPMC12547815

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.