Evidence map›Paper›PMID 41142991›Full record

ArticleiScience2025

Light-evoked activity and BDNF regulate mitochondrial dynamics and mitochondrial localized translation in CNS axons.

Alexander Kreymerman, Jessica E Weinstein, Nirmal Vadgama, Sahil H Shah, Michael M Nahmou, Kinsley C Belle, Marco H Ji, Xin Xia, Anne Faust, Yolandi Van Der Merwe and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Alexander KreymermanSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Jessica E WeinsteinUniversity of Miami Miller School of Medicine, Miami, FL 33136, USA.
Nirmal VadgamaCardiovascular Institute, Stanford School of Medicine, Stanford, CA 94303, USA.
Sahil H ShahSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Michael M NahmouSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Kinsley C BelleSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Marco H JiSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Xin XiaSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Anne FaustDepartment of Ophthalmology and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Yolandi Van Der MerweDepartment of Ophthalmology and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
David N BuickiansSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
In-Jae ChoSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Star K HuynhSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Sonya VermaSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Kristina RussanoSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Xiao-Lu JinUniversity of Miami Miller School of Medicine, Miami, FL 33136, USA.
Ioannis KarakikesCardiovascular Institute, Stanford School of Medicine, Stanford, CA 94303, USA.
Michael B SteketeeUniversity of Miami Miller School of Medicine, Miami, FL 33136, USA.
Jeffrey L GoldbergSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.

Funding

The role of mitochondrial fission/fusion in CNS axon regenerationF31NS087789 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI KREYMERMAN, ALEXANDER · 2014 to 2016
$81k
NINDS NIH HHS F31 NS087789
6 · The paper itself

Abstract

Mitochondria coordinate well-described maintenance functions within neuronal axons and dendrites. However, less is known about how mitochondria are regulated during axon development and maturation. Here, we demonstrate that within the developing visual system, retinal ganglion cell (RGC) axons in the retina and optic nerve exhibit increases in mitochondria size, number, and total area

Indexed as

Biological sciencesNatural sciencesNeuroscienceSystems neuroscience

Identifiers

PMID41142991
PMCPMC12547173

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.