Evidence map›Paper›PMID 41143154›Full record

ArticleJBMR plus2025

Utilizing CRISPR-Cas13d-knockdown in zebrafish to study a rare monogenic bone fragility syndrome.

Kirsi Määttä, Yu-Chia Chen, Sandra Pihlström, Riikka E Mäkitie, Emilie Dambroise, Laurence Legeai-Mallet, Pertti Panula, Outi Mäkitie, Minna Pekkinen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. PathogenicFrontiers in endocrinology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kirsi MäättäFolkhälsan Research Center, Genetics Research Program, 00290 Helsinki, Finland.
Yu-Chia ChenDepartment of Anatomy, 00014 University of Helsinki, Helsinki, Finland.
Sandra PihlströmFolkhälsan Research Center, Genetics Research Program, 00290 Helsinki, Finland.
Riikka E MäkitieFolkhälsan Research Center, Genetics Research Program, 00290 Helsinki, Finland.
Emilie DambroiseLaboratory of Genetics of Developmental Disorders, INSERM UMR 1163, Université Paris Cité, Imagine Institute, 75015 Paris, France.
Laurence Legeai-MalletLaboratory of Genetics of Developmental Disorders, INSERM UMR 1163, Université Paris Cité, Imagine Institute, 75015 Paris, France.ORCID https://orcid.org/0000-0003-4989-5856
Pertti PanulaDepartment of Anatomy, 00014 University of Helsinki, Helsinki, Finland.
Outi MäkitieFolkhälsan Research Center, Genetics Research Program, 00290 Helsinki, Finland.ORCID https://orcid.org/0000-0002-4547-001X
Minna PekkinenFolkhälsan Research Center, Genetics Research Program, 00290 Helsinki, Finland.ORCID https://orcid.org/0000-0003-2947-4683

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic variants in the human

Indexed as

calvarial doughnut lesions with bone fragilityearly-onset osteoporosissphingomyelin metabolismsphingomyelin synthase 2zebrafish

Identifiers

PMID41143154
PMCPMC12548727

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.