Evidence map›Paper›PMID 41143504›Full record

ArticleeLife2025

Tonotopy is not preserved in a descending stage of auditory cortex.

Miaoqing Gu, Shanshan Liang, Jiahui Zhu, Ruijie Li, Ke Liu, Xuanyue Wang, Frank W Ohl, Yun Zhang, Xiang Liao, Chunqing Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Miaoqing Gu *School of Physical Science and Technology, Guangxi University, Nanning, China.
Shanshan Liang *Brain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Jiahui ZhuGuangxi Key Laboratory of Special Biomedicine and Advanced Institute for Brain and Intelligence, School of Medicine, Guangxi University, Nanning, China.
Ruijie LiBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Ke LiuBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Xuanyue WangBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Frank W OhlLeibniz Institute for Neurobiology (LIN), Magdeburg, Germany.
Yun ZhangState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, China.
Xiang LiaoSchool of Medicine, Center for Neurointelligence, Chongqing University, Chongqing, China.
Chunqing ZhangInstitute of Brain and Intelligence, Third Military Medical University, Chongqing, China.
Hongbo JiaSchool of Physical Science and Technology, Guangxi University, Nanning, China.ORCID https://orcid.org/0000-0003-1585-2161
Yi ZhouDepartment of Military Cognitive Psychology, School of Psychology, Third Military Medical University, Chongqing, China.
Jianxiong ZhangBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.
Xiaowei ChenBrain Research Center and State Key Laboratory of Trauma and Chemical Poisoning, Third Military Medical University, Chongqing, China.ORCID https://orcid.org/0000-0003-0906-6666

Funding

Guangxi Science and Technology Base & Talents Fund GUIKE AD22035948Jiangsu Provincial Big Science Facility Initiative BM2022010National Key Research and Development Program of China 2021YFA0805000National Natural Science Foundation of China 31925018National Natural Science Foundation of China 32127801National Natural Science Foundation of China 32300937National Natural Science Foundation of China T2241002
6 · The paper itself

Abstract

Previous studies based on layer specificity suggest that ascending signals from the thalamus to the sensory neocortex preserve spatially organized information, but it remains unknown whether sensory information descending from sensory neocortex to the thalamus also maintains such spatial organization pattern. By focusing on projection specificity, we mapped the tone response properties of two groups of cortical neurons in the primary auditory cortex (A1), based on the relationship between their specific connections to other regions and their function in ascending (thalamocortical recipient [TR] neurons) or descending (corticothalamic [CT] neurons) auditory information. A clear tonotopic gradient was observed among TR neurons, but not CT neurons. Additionally, CT neurons exhibited markedly higher heterogeneity in their frequency tuning and had broader bandwidth than TR neurons. These results reveal that the information flow descending from A1 to the thalamus via CT neurons is not arranged tonotopically, suggesting that the descending information flow possibly contributes to higher-order feedback processing of diverse auditory inputs.

Indexed as

Auditory CortexAuditory PathwaysAuditory PerceptionNeuronsThalamusAcoustic StimulationAnimalsauditory cortexcorticothalamic neuronheterogeneitymouseneurosciencetonotopic maptwo-photon imaging

Identifiers

PMID41143504
PMCPMC12558652

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.