Evidence map›Paper›PMID 41144014›Full record

ArticleBrain structure & function2025

Differential gray and white matter alterations in children with complete and incomplete spinal cord injuries: a preliminary MRI study using voxel-based morphometry and tract-based spatial statistics.

Beining Yang, Yu Wang, Haotian Xin, Ling Wang, Qunya Qi, Yulong Jia, Xianglin Guo, Weimin Zheng, Chuchu Sun, Xin Chen and 4 more

Abstract read
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Article in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Beining Yang *Department of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Yu Wang *Department of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Haotian XinDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Ling WangDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Qunya QiDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Yulong JiaDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Xianglin GuoDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Weimin ZhengDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Chuchu SunDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Xin ChenDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Jubao DuDepartment of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Yongsheng HuDepartment of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Jie LuDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Nan ChenDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. chenzen8057@sina.com.

Funding

Huizhi Talent Project - Training program - leading talent 007201-0072250National Natural Science Foundation of China 81871339 and 81271556
6 · The paper itself

Abstract

Brain gray matter (GM) and white matter alterations have been studied in pediatric spinal cord injury (SCI) patients. However, the differences in brain reorganization between complete SCI (CSCI) and incomplete SCI (ICSCI) remain unclear. The objective of the study was to explore the different effects of CSCI and ICSCI on brain structure in pediatric patients. A total of 68 children with SCI (37 with CSCI and 31 with ICSCI) and 36 age-matched healthy controls (HCs) were enrolled. The clinical data on motor and sensory scores, degree of injury, duration of injury, and age at the time of injury were assessed. GM volume (GMV) and diffusion tensor imaging (DTI) indices were analyzed using voxel-based morphometry and tract-based spatial statistics. Both CSCI and ICSCI patients exhibited abnormalities in GMV and DTI metrics within brain regions associated with sensorimotor functions, emotional processing, and pain perception. Notably, the ICSCI group showed significantly reduced GMV in the left thalamus (p < 0.001, t = - 5.275), right caudate nucleus (p < 0.001, t = - 4.992), and left precuneus (p = 0.002, t = - 4.053) compared to the CSCI group. Our study showed that pediatric patients with CSCI and ICSCI exhibit distinct patterns of GM reorganization in regions involved in sensory processing and cognitive functions.

Indexed as

BrainGray MatterSpinal Cord InjuriesWhite MatterAdolescentChildDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleBrain reorganizationComplete spinal cord injuryIncomplete spinal cord injuryTract‐based spatial statisticsVoxel-based morphometry

Identifiers

PMID41144014

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.